PROGRAMME
| DAY 1 | SATURDAY | 20 JUNE 2015 | ||
| 16:00 - 17:30 | WELCOME COCKTAIL | |
| 17.30-18.00 | WELCOME | |
| Claudio Sunkel, IBMC Director | ||
| 18.00-20.00 | Chair: Giampietro Schiavo, University College London, UK | |
| 18.00 – 19.00 | THE EMBO KEYNOTE LECTURE | |
| Klaus Aktories Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, DepAlbert-Ludwigs-Universität Freiburg, Freiburg, Germany |
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| 19.00 – 19.20 | Tribute to Joseph Alouf (1929-2014) | |
| Michel R. Popoff, Institut Pasteur, Paris, France | ||
| 19.20 – 19.40 | Tribute to Sjur Olsnes | |
| John Collier, Harvard Medical School, Boston, USA | ||
| 19.40 – 20.00 | ETOX thematic issue in Pathogens and Disease, a journal of the Federation of European Microbiological Societies | |
| Patrik Bavoil, University of Maryland, Baltimore, USA | ||
| 20.00 – 21.30 | DINNER | |
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| DAY 2 | SUNDAY | 21 JUNE 2015 | ||
| 09.00 – 13.00 | SESSION I: GENETICS, EXPRESSION AND SECRETION | |
| Chair: Randall Holmes, University of Colorado School of Medicine, USA | ||
| 09.00 – 09.30 | Genetics and expression of Clostridium botulinum neurotoxin | |
| Mike William Peck, Institute of Food Research, UK | ||
| 09.30 – 10.00 | Unravelling hidden roles of microRNAs in bacterial pathogen-host interaction | |
| Ana Eulálio, Institute for Molecular Infection Biology, University of Wurzburg, Germany | ||
| 10.00 – 10.30 | Bacterial Persistence, Pathogenesis and Toxin-Antitoxin Systems | |
| Nancy Woychik, Robert Wood Johnson Medical School, New Jersey, USA | ||
| 10.30 – 11.00 | COFFEE BREAK | |
| Chair: Christoph Dehio, Biozentrum, University of Basel, Switzerland | ||
| 11.00 – 11.30 | Structural and molecular biology of Type IV secretion systems | |
| Gabriel Waksman, Institute of Structural and Molecular Biology, Birkbeck College and UCL, UK | ||
| 11.30 – 12.00 | Structure, function and dynamics of Type VI secretion system | |
| Marek Basler, University of Basel, Switzerland | ||
| 12.00 – 12.15 | Structural basis for the activation of bacterial pore-forming toxins / POSTER 26 Allister Crow, Pathology Department, University of Cambridge, UK |
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| 12.15 – 12.30
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The link between toxin production and spore formation in the intestinal pathogen Costridium difficile / POSTER 63 Carolina P. Cassona, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Portugal |
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| 12.30 – 14.00 | LUNCH | |
| 14.00 – 16.00 | POSTER SESSION | |
| 16.00 – 19.30 | SESSION II: RECEPTORS, TRAFFICKING AND TRANSLOCATION MECHANISMS I | |
| Chair: Klaus Aktories, University of Freiburg, Germany | ||
| 16.00 – 16.30 |
Entry of Tetanus Toxin into Neurons- A heterologous reporter defines the role of the tetanus toxin inter-chain disulfide in Light Chain translocation | |
| Joseph T. Barbieri, Medical College of Wisconsin, USA | ||
| 16.30 – 17.00 | The receptor of Tetanus Toxin at the neuromuscular junction | |
| Giampietro Schiavo, University College London, UK | ||
| 17.00 - 17.30 | COFFEE BREAK | |
| Brenda Wilson, University of Illinois, USA | ||
| 17.30 – 18.00 | Botulinum Neurotoxins: From mechanism of action to the development of pan-inhibitors | |
| Marco Pirazzini, University of Padova, Italy | ||
| 18.00 – 18.30 | Genes, Pathways and Domains Involved in the Uptake of Clostridial Glycosylating Toxins | |
| Panagiotis Papatheodorou, University of Freiburg, Germany | ||
| 18.30 – 19.00 | Salmonella virulence effector subversion of Myosin VI controls phosphopinositide dynamics and cytoskeleton remodelling to drive host cell invasion | |
| Daniel Humphreys, University of Cambridge, UK | ||
| 19.00 – 19.15 |
Toxin-induced dissemination of bacteria through transendothelial cell tunnels / POSTER 10 Emmanuel Lemichez, Centre Méditerranéen de Médecine Moléculaire, C3M, INSERM U1065, Université de Nice-Sophia-Antipolis, Nice, France |
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| 19.15 – 19.30 |
Unraveling the Mechanisms of Membrane Translocation by the Large Glucosylating Toxins of C. difficile / POSTER 21 Roman A. Melnyk, Research Institute at the Hospital for Sick Children, University of Toronto, Canada |
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| 20.00 – 21.30 | DINNER | |
| 21.30 – 22.30 | POSTER SESSION | |
| DAY 3 | MONDAY | 22 JUNE 2015 | ||
| 09.00 – 12.00 | SESSION III: RECEPTORS, TRAFFICKING AND TRANSLOCATION MECHANISMS II | |
| Chair: Vassilis Koronakis, Cambridge University, UK | ||
| 09.00 – 09.30 | The adenylate cyclase toxin: How it work and what does it do | |
| Peter Sebo, Institute of Microbiology of the ASCR, Prague, Czech Republic | ||
| 09.30 – 10.00 | Staphylococcal bicomponent leukotoxins: not only pore-forming toxins | |
| Gilles Prévost, University of Strasbourg, France | ||
| 10.00 – 10.30 | Analyzing the cell biological mechanisms of barrier disrupting bacterial toxins | |
| Ethan Bier, University of California San Diego, USA | ||
| 10.30 – 11.00 | COFFEE BREAK | |
| 11.00 – 11.15 | AIP56: a short-trip AB toxin with a peculiar translocation domain / POSTER 78 José Peres, Fish Immunology & Vaccinology Group, IBMC - Instituto de Biologia Celular e Molecular, Porto, Portugal |
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| 11.15 – 11.30 | Actin Crosslinking Domain toxins of Vibrio and Aeromonas spp. initiate a poisoning cascade to block formin-controlled
actin polymerization / POSTER 01 Elena Kudryashova, Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA |
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| 11.30 – 12.30 | SESSION IV: TARGETS, SIGNALING AND HOST CELL RESPONSES | |
| Chair: Gilles Prévost, University of Strasbourg, France | ||
| 11.30 – 12.00 | How C. perfringens Epsilon toxin attacks cells of the nervous system | |
| Bernard Poulain, University of Strasbourg, France | ||
| 12.00 – 12.30 | Host cell survival responses to the pore-forming toxin LLO: cytoskeleton and ER partnership | |
| Sandra Sousa, IBMC, Porto, Portugal | ||
| 12.30 – 14.30 | LUNCH | |
| 14.30 – 19.00 | FREE AFTERNOON AT OPORTO | |
| 19.00 – 22.30 | GUIDED VISIT TO OPORTO WINE CELLARS AND CONGRESS DINNER AT CELLARS | |
| DAY 4 | TUESDAY | 23 JUNE 2015 | ||
| 09.00 – 12.30 | SESSION IV: TARGETS, SIGNALING AND HOST CELL RESPONSES | |
| Chair: Teresa Frisan, Karolinska Institutet, Sweden | ||
| 09.00 – 09.30 | Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome | |
| Feng Shao, National Institute of Biological Sciences, Beijing, China | ||
| 09.30 – 10.00 | Structural Basis of Bacterial ADP-ribosyltransferase and Human Protein Complex | |
| Hideaki Tsuge, Kyoto Sangyo University, Japan | ||
| 10.00 – 10.30 | HlyF : a fake toxin but a real virulence factor | |
| Eric Oswald, University of Toulouse, France | ||
| 10.30 – 11.00 | COFFEE BREAK | |
| 11.00 – 11.30 | The typhoid toxin enhances the host fitness and promotes chronic infection | |
| Teresa Frisan, Karolinska Institutet, Sweden | ||
| 11.30 – 12.00 | CRISPR/Cas9-mediated gene knockout screening for the identification of host components essential for bacterial toxicity | |
| Wensheng Wei, Peking University, China | ||
| 12.00 – 12.15 | The recently discovered ExlA toxin from Pseudomonas aeruginosa induces E-cadherin cleavage/ POSTER 28 Philippe Huber, UMR1036, Inserm-CNRS-CEA-Grenoble Alpes University, Grenoble, France |
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| 12.15 – 12.30 | MARTX effector domain specifically processes the Switch I region of Ras and Rap / POSTER 02 Marco Biancucci, Feinberg School of Medicine, Northwestern University, Chicago, USA |
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| 12.30 – 14.00 | LUNCH | |
| 14.00 – 16.00 | POSTER SESSION | |
| 16.00 – 19.30 | SESSION V: PATHOGENESIS AND IMMUNITY | |
| Chair: Joseph Barbieri, Medical College of Wiscosin, USA | ||
| 16.00 – 16.30 | SFB: a gut commensal with pathogenic patterns to educate the host | |
| Pamela Schnupf, Laboratory of Intestinal Immunity, Imagine Institute, Paris, France | ||
| 16.30 – 17.00 | Immune evasion by staphylococcal toxins | |
| J.A.G. (Jos) van Strijp, Medical Microbiology UMC Utrecht, the Netherlands | ||
| 17.00 – 17.30 | COFFEE BREAK | |
| Chair: Feng Shao, Medical College of Wisconsin, USA | ||
| 17.30 – 18.00 | Helicobacter pylori in health and disease | |
| Anne Müller, University of Zurich, Switzerland | ||
| 18.00 – 18.30 | Anti-chaperone activity of human defense peptides against bacterial toxins and viral proteins | |
| Dmitri S. Kudryashov, The Ohio State University, USA | ||
| 18.30 – 19.00 | Salmonella type III effectors: manipulation of host inflammatory response | |
| Jana Kamanova, Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA | ||
| 19.00 – 19.15 | Type A botulinum neurotoxin complex exploits intestinal M cells to enter the host and exert neurotoxicity
/ POSTER 36 Takukuhiro Matsumura, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Japan |
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| 19.15 – 19.30 | Pasteurella multocida Toxin manipulates T cell differentiation / POSTER 46 Katharina F. Kubatzky, Medizinische Mikrobiologie und Hygiene, Heidelberg, Germany |
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| 20.00 – 21.30 | DINNER | |
| DAY 5 | WEDNESDAY | 24 JUNE 2015 | ||
| 09.00 – 12.30 | SESSION V: APPLICATIONS SESSION | |
| Chair: John Collier, Harvard Medical School, Boston, Massachusetts, USA | ||
| 09.00 – 09.30 | Investigating the role of the protein antigens of the new vaccine against serogroup B Neisseria meningitidis (Bexsero) during meningococcal infection | |
| Vega Masignani, GSK Vaccines, Italy | ||
| 09.30 – 10.00 | Re-engineering botulinum neurotoxins for novel therapeutic applications | |
| Thomaz Binz, Hanover Medical School, Germany | ||
| 10.00 – 10.30 | Dihydroquinazolinones inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from filoviruses, Chlamydiales and Leishmania | |
| Daniel Gillet, SIMOPRO-iBiTec-S, CEA, Saclay, France | ||
| 10.30 – 11.00 | COFFEE BREAK | |
| Chair: Peter Sebo, Institute of Microbiology of the ASCR, Czech Academy of Sciences, Prague, Czech Republic | ||
| 11.00 – 11.30 | CNFs for cancer therapy? | |
| Gudula Schmidt, University of Freiburg, Germany | ||
| 11.30 – 12.00 | Portals and Pathways: Bacterial Toxin Entry into Host Cells | |
| Kenneth Bradley, UCLA, USA | ||
| 12.00 – 12.15 | EGA prevents the neuronal toxicity of BoNT/A and BoNT/B / POSTER 05 Domenico Azarnia Tehran, Department of Biomedical Sciences and National Research Council Institute of Neuroscience, University of Padova, Italy | |
| 12.15 – 12.30 | Toxin-mediated delivery of antigens into dendritic cells for stimulation of T cells / POSTER 68 Catarina Nogueira, Harvard Medical School, Boston, Massachusetts, USA |
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| 12.30 – 13.00 | SUMMARY OF MEETING | |
| Joseph T. Barbieri, Medical College of Wisconsin, USA | ||
| 13.00 – 14.30 | LUNCH AND DEPARTURE | |
Rua do Campo Alegre, 823, 4150-180 Porto - Portugal
Tel +351 226 074 900 . Email: RITA.MATOS@ibmc.up.pt