TY - JOUR T1 - Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation JF - Scientific Reports Y1 - 2017 A1 - Sant'Anna, R. A1 - Almeida, M.R. A1 - Varejao, N. A1 - Gallego, P. A1 - Esperante, S. A1 - Ferreira, P. A1 - Pereira-Henriques, A. A1 - Palhano, F.L. A1 - De Carvalho, M. A1 - Foguel, D. A1 - Reverter, D. A1 - Saraiva, M.J. A1 - Ventura, S. VL - 7 UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85016162023&doi=10.1038%2fsrep44709&partnerID=40&md5=6051bd41c380b3c50cbaccf2b26a80af N1 - Export Date: 19 March 2018 ER - TY - JOUR T1 - Curcumin: A multi-Target disease-modifying agent for late-stage transthyretin amyloidosis JF - Scientific Reports Y1 - 2016 A1 - Ferreira, N. A1 - Gonçalves, N.P. A1 - Saraiva, M.J. A1 - Almeida, M.R. VL - 6 UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-84969921377&doi=10.1038%2fsrep26623&partnerID=40&md5=6dba1ba0bad80de99de6426044ae291c N1 - Cited By :10Export Date: 19 March 2018 ER - TY - JOUR T1 - A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition JF - European Journal of Medicinal Chemistry Y1 - 2016 A1 - Simões, C.J.V. A1 - Almeida, Z.L. A1 - Costa, D. A1 - Jesus, C.S.H. A1 - Cardoso, A.L. A1 - Almeida, M.R. A1 - Saraiva, M.J. A1 - Pinho e Melo, T.M.V.D. A1 - Brito, R.M.M. VL - 121 UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961839171&doi=10.1016%2fj.ejmech.2016.02.074&partnerID=40&md5=0f10f2da86425912e522ce94860d41a3 N1 - Cited By :1Export Date: 19 March 2018 ER - TY - JOUR T1 - Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity JF - Nature Communications Y1 - 2016 A1 - Sant'Anna, R. A1 - Gallego, P. A1 - Robinson, L.Z. A1 - Pereira-Henriques, A. A1 - Ferreira, N. A1 - Pinheiro, F. A1 - Esperante, S. A1 - Pallares, I. A1 - Huertas, O. A1 - Almeida, M.R. A1 - Reixach, N. A1 - Insa, R. A1 - Velazquez-Campoy, A. A1 - Reverter, D. A1 - Reig, N. A1 - Ventura, S. VL - 7 UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-84959087061&doi=10.1038%2fncomms10787&partnerID=40&md5=3e7387be5aa84dc7acb440550ae5e2ec N1 - Cited By :22Export Date: 19 March 2018 ER - TY - JOUR T1 - Transthyretin chemical chaperoning by flavonoids: Structure-activity insights towards the design of potent amyloidosis inhibitors JF - Biochemistry and Biophysics Reports Y1 - 2015 A1 - Ferreira, N. A1 - Pereira-Henriques, A. A1 - Almeida, M.R. VL - 3 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84939508272&partnerID=40&md5=0689f3aa27b7e487c210e2c3353bc19a N1 - Export Date: 12 January 2016 ER - TY - JOUR T1 - Dietary curcumin counteracts extracellular transthyretin deposition: Insights on the mechanism of amyloid inhibition JF - Biochimica et Biophysica Acta - Molecular Basis of Disease Y1 - 2013 A1 - Ferreira, N. A1 - Santos, S. A. O. A1 - Domingues, M. R. M. A1 - Saraiva, M.J. A1 - Almeida, M.R. VL - 1832 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84868592337&partnerID=40&md5=647a1c6ab2e5ab9f8d22abea13273854 IS - 1 N1 - Export Date: 18 March 2013Source: Scopus ER - TY - JOUR T1 - Clearance of extracellular misfolded proteins in systemic amyloidosis: Experience with transthyretin JF - FEBS Letters Y1 - 2012 A1 - Almeida, M.R. A1 - Saraiva, M.J. VL - 586 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84864931018&partnerID=40&md5=7e26ae250f6b885e94435e7a9b447aae IS - 18 N1 - Export Date: 18 March 2013Source: Scopus ER - TY - JOUR T1 - Epigallocatechin-3-gallate as a potential therapeutic drug for TTR-related amyloidosis: "In vivo" evidence from FAP mice models JF - PLoS ONE Y1 - 2012 A1 - Ferreira, N. A1 - Saraiva, M.J. A1 - Almeida, M.R. VL - 7 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84855650426&partnerID=40&md5=3a4219629a4b3d658732a82d3448a7e4 IS - 1 N1 - Cited By (since 1996): 7Export Date: 18 March 2013Source: ScopusArt. No.: e29933 ER - TY - JOUR T1 - Natural polyphenols as modulators of TTR amyloidogenesis: In vitro and in vivo evidences towards therapy JF - Amyloid Y1 - 2012 A1 - Ferreira, N. A1 - Saraiva, M.J. A1 - Almeida, M.R. VL - 19 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84861433687&partnerID=40&md5=850a84457e12b3b1a1ebabc339a6f5c8 IS - SUPPL. 1 N1 - Cited By (since 1996): 1Export Date: 18 March 2013Source: Scopus ER - TY - JOUR T1 - Transthyretin deposition in familial amyloidotic polyneuropathy JF - Current Medicinal Chemistry Y1 - 2012 A1 - Saraiva, M.J. A1 - Magalhaes, J. A1 - Ferreira, N. A1 - Almeida, M.R. VL - 19 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84860663436&partnerID=40&md5=962004f2e8e201193cd9a0e0f5657bee IS - 15 N1 - Cited By (since 1996): 2Export Date: 18 March 2013Source: Scopus ER - TY - JOUR T1 - Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation JF - FEBS Letters Y1 - 2011 A1 - Ferreira, N. A1 - Saraiva, M.J. A1 - Almeida, M.R. VL - 585 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-79960910835&partnerID=40&md5=280da17ba91b02d23308cfcba9f21a31 IS - 15 N1 - Cited By (since 1996): 17Export Date: 18 March 2013Source: Scopus ER - TY - JOUR T1 - Functional characterization of Arabidopsis thaliana transthyretin-like protein JF - BMC Plant Biology Y1 - 2010 A1 - Pessoa, J. A1 - Sárkány, Z. A1 - Ferreira-Da-Silva, F. A1 - Martins, S. A1 - Almeida, M.R. A1 - Li, J. A1 - Damas, A.M. VL - 10 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-77949472438&partnerID=40&md5=c7268ff6b1d99880ceaf1c6cf6512157 N1 - Cited By (since 1996): 6Export Date: 18 March 2013Source: ScopusArt. No.: 30 ER - TY - JOUR T1 - Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin JF - FEBS Journal Y1 - 2010 A1 - Martinho, A. A1 - Gonçalves, I. A1 - Cardoso, I. A1 - Almeida, M.R. A1 - Quintela, T. A1 - Saraiva, M.J. A1 - Santos, C.R.A. VL - 277 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-77955239777&partnerID=40&md5=8e3d909df1ca346d05af4045651d0b7d IS - 16 N1 - Cited By (since 1996): 10Export Date: 18 March 2013Source: Scopus ER - TY - JOUR T1 - Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity JF - FEBS Letters Y1 - 2009 A1 - Ferreira, N. A1 - Cardoso, I. A1 - Domingues, M.R. A1 - Vitorino, R. A1 - Bastos, M. A1 - Bai, G. A1 - Saraiva, M.J. A1 - Almeida, M.R. VL - 583 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-71749085436&partnerID=40&md5=811ef79e7b3739a73a8a833f12c37ec5 IS - 22 N1 - Cited By (since 1996): 20Export Date: 18 March 2013Source: Scopus ER - TY - JOUR T1 - Iodine atoms: A new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors JF - PLoS ONE Y1 - 2009 A1 - Mairal, T. A1 - Nieto, J. A1 - Pinto, M. A1 - Almeida, M.R. A1 - Gales, L. A1 - Ballesteros, A. A1 - Barluenga, J. A1 - Pérez, J.J. A1 - Vázquez, J.T. A1 - Centeno, N.B. A1 - Saraiva, M.J. A1 - Damas, A.M. A1 - Planas, A. A1 - Arsequell, G. A1 - Valencia, G. VL - 4 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-76549107471&partnerID=40&md5=3c50b3f528228e1cdcbdf338d86ca8ca IS - 1 N1 - Cited By (since 1996): 3Export Date: 18 March 2013Source: ScopusArt. No.: e4124 ER - TY - JOUR T1 - Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors. JF - PLoS ONE Y1 - 2009 A1 - Mairal, T. A1 - Nieto, J. A1 - Pinto, M. A1 - Almeida, M.R. A1 - Gales, L. A1 - Ballesteros, A. A1 - Barluenga, J. A1 - Pérez, J.J. A1 - Vázquez, J.T. A1 - Centeno, N.B. A1 - Saraiva, M.J. A1 - Damas, A.M. A1 - Planas, A. A1 - Arsequell, G. A1 - Valencia, G. VL - 4 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-59249100931&partnerID=40&md5=f198d6ea26cef74066becb41f537c7cd IS - 1 N1 - Cited By (since 1996): 11Export Date: 18 March 2013Source: Scopus ER - TY - JOUR T1 - Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors JF - Bioorganic and Medicinal Chemistry Letters Y1 - 2009 A1 - González, A. A1 - Quirante, J. A1 - Nieto, J. A1 - Almeida, M.R. A1 - Saraiva, M.J. A1 - Planas, A. A1 - Arsequell, G. A1 - Valencia, G. VL - 19 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-68549085257&partnerID=40&md5=b4cf7ffd46ddb61e0d802b209c39334d IS - 17 N1 - Cited By (since 1996): 10Export Date: 18 March 2013Source: Scopus ER - TY - JOUR T1 - Substrate specificity of transthyretin: Identification of natural substrates in the nervous system JF - Biochemical Journal Y1 - 2009 A1 - Liz, M.A. A1 - Fleming, C.E. A1 - Nunes, A.F. A1 - Almeida, M.R. A1 - Mar, F.M. A1 - Choe, Y. A1 - Craik, C.S. A1 - Powers, J.C. A1 - Bogyo, M. A1 - Sousa, M.M. VL - 419 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-64249132020&partnerID=40&md5=1051f7c3a610d20ad4abb5e20dbd9dc3 IS - 2 N1 - Cited By (since 1996): 14Export Date: 18 March 2013Source: Scopus ER - TY - JOUR T1 - Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy JF - Biochimica et Biophysica Acta - Molecular Basis of Disease Y1 - 2008 A1 - Macedo, B. A1 - Batista, A.R. A1 - Ferreira, N. A1 - Almeida, M.R. A1 - Saraiva, M.J. VL - 1782 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-49349097870&partnerID=40&md5=0504bdb8449a5ce447da5feb06674ee6 IS - 9 N1 - Cited By (since 1996): 15Export Date: 18 March 2013Source: Scopus ER - TY - JOUR T1 - Iodination of salicylic acid improves its binding to transthyretin JF - Biochimica et Biophysica Acta - Proteins and Proteomics Y1 - 2008 A1 - Gales, L. A1 - Almeida, M.R. A1 - Arsequell, G. A1 - Valencia, G. A1 - Saraiva, M.J. A1 - Damas, A.M. VL - 1784 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-43049162388&partnerID=40&md5=ef1bf96239ccea9c357c15a1c430e7d9 IS - 3 N1 - Cited By (since 1996): 6Export Date: 18 March 2013Source: Scopus ER - TY - JOUR T1 - Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: Relevance in drug design JF - Biochemical Journal Y1 - 2007 A1 - Cardoso, I. A1 - Almeida, M.R. A1 - Ferreira, N. A1 - Arsequell, G. A1 - Valencia, G. A1 - Saraiva, M.J. VL - 408 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-36348960658&partnerID=40&md5=a11be6d9183785b213d1ee7ad796276b IS - 1 N1 - Cited By (since 1996): 13Export Date: 18 March 2013Source: Scopus ER - TY - JOUR T1 - Interaction with human plasminogen system turns on proteolytic activity in Streptococcus agalactiae and enhances its virulence in a mouse model JF - Microbes and Infection Y1 - 2007 A1 - Magalhães, V. A1 - Veiga-Malta, I. A1 - Almeida, M.R. A1 - Baptista, M. A1 - Ribeiro, A. A1 - Trieu-Cuot, P. A1 - Ferreira, P. VL - 9 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-35148826082&partnerID=40&md5=837fad04bb1154c2afcf7ec011494e55 IS - 11 N1 - Cited By (since 1996): 16Export Date: 18 March 2013Source: Scopus ER - TY - JOUR T1 - Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses JF - Current Drug Targets: CNS and Neurological Disorders Y1 - 2005 A1 - Almeida, M.R. A1 - Gales, L. A1 - Damas, A.M. A1 - Cardoso, I. A1 - Saraiva, M.J. VL - 4 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-26844484754&partnerID=40&md5=af4ca78d8342a69428684780d78b9e87 IS - 5 N1 - Cited By (since 1996): 22Export Date: 18 March 2013Source: Scopus ER - TY - JOUR T1 - Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative JF - Biochemical Journal Y1 - 2004 A1 - Almeida, M.R. A1 - Macedo, B. A1 - Cardoso, I. A1 - Alves, I. A1 - Valencia, G. A1 - Arsequell, G. A1 - Planas, A. A1 - Saraiva, M.J. VL - 381 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-3242807241&partnerID=40&md5=747dfb0a22bc2fdaf7dab5fea48b8f21 IS - 2 N1 - Cited By (since 1996): 36Export Date: 18 March 2013Source: Scopus ER -