Gimeno, A., Santos, L. M., Alemi, M., Rivas, J., et al. (2017). Insights on the Interaction between Transthyretin and A? in Solution. A Saturation Transfer Difference (STD) NMR Analysis of the Role of Iododiflunisal. Journal of Medicinal Chemistry, 60(13), 5749 - 5758.

Silva, C. S., Eira, J., Ribeiro, C. A., Oliveira, Â., et al. (2017). Transthyretin neuroprotection in Alzheimer's disease is dependent on proteolysis. Neurobiology of Aging, 59, 10 - 14.

Alemi, M., Silva, S. C., Santana, I., & Cardoso, I. (2017). Transthyretin stability is critical in assisting beta amyloid clearance? Relevance of transthyretin stabilization in Alzheimer's disease. CNS Neuroscience and Therapeutics, 23(7), 605 - 619.

Santos, L. M., Rodrigues, D., Alemi, M., Silva, S. C., et al. (2016). Resveratrol administration increases transthyretin protein levels, ameliorating AD features: The importance of transthyretin tetrameric stability. Molecular Medicine, 22, 597 - 607.

Alemi, M., Gaiteiro, C., Ribeiro, C. A., Santos, L. M., et al. (2016). Transthyretin participates in beta-amyloid transport from the brain to the liver- involvement of the low-density lipoprotein receptor-related protein 1?. Scientific Reports, 6.

Leal, S. S., Cristóvão, J. S., Biesemeier, A., Cardoso, I., & Gomes, C. M. (2015). Aberrant zinc binding to immature conformers of metal-free copper-zinc superoxide dismutase triggers amorphous aggregation. Metallomics, 7(2), 333 - 346.

Loureiro, J. A., Gomes, B., Fricker, G., Cardoso, I., et al. (2015). Dual ligand immunoliposomes for drug delivery to the brain. Colloids and Surfaces B: Biointerfaces, 134, 213 - 219.

Conejos-Sánchez, I., Cardoso, I., Oteo-Vives, M., Romero-Sanz, E., et al. (2015). Polymer-doxycycline conjugates as fibril disrupters: An approach towards the treatment of a rare amyloidotic disease. Journal of Controlled Release, 198, 80 - 90.

Conejos-Sánchez, I., Cardoso, I., Saraiva, M. J., & Vicent, M. J. (2014). Targeting a rare amyloidotic disease through rationally designed polymer conjugates. Journal of Controlled Release, 178(1), 95 - 100.

Ribeiro, C. A., Oliveira, S. M., Guido, L. F., Magalhães, A., et al. (2014). Transthyretin stabilization by iododiflunisal promotes amyloid-? peptide clearance, decreases its deposition, and ameliorates cognitive deficits in an Alzheimer's disease mouse model. Journal of Alzheimer's Disease, 39(2), 357 - 370.

Leal, S. S., Cardoso, I., Valentine, J. S., & Gomes, C. M. (2013). Calcium ions promote superoxide dismutase 1 (SOD1) aggregation into non-fibrillar amyloid: A link to toxic effects of calcium overload in amyotrophic lateral sclerosis (ALS)?. Journal of Biological Chemistry, 288(35), 25219 - 25228.

Paiva, D., Martín-Molina, A., Cardoso, I., Quesada-Pérez, M., et al. (2013). The effect of a fluorinated cholesterol derivative on the stability and physical properties of cationic DNA vectors. Soft Matter, 9(2), 401 - 409.

Carvalho, S. B., Botelho, H. M., Leal, S. S., Cardoso, I., et al. (2013). Intrinsically Disordered and Aggregation Prone Regions Underlie ?-Aggregation in S100 Proteins. PLoS ONE, 8(10).

Cristóvão, J. S., Leal, S. S., Cardoso, I., & Gomes, C. M. (2013). Small molecules present in the cerebrospinal fluid metabolome influence superoxide dismutase 1 aggregation. International Journal of Molecular Sciences, 14(9), 19128 - 19145.

Ribeiro, C. A., Saraiva, M. J., & Cardoso, I. (2012). Stability of the Transthyretin Molecule as a Key Factor in the Interaction with A-Beta Peptide - Relevance in Alzheimer's Disease. PLoS ONE, 7(9).

Ribeiro, C. A., Santana, I., Oliveira, C., Baldeiras, I., et al. (2012). Transthyretin decrease in plasma of MCI and AD patients: Investigation of mechanisms for disease modulation. Current Alzheimer Research, 9(8), 881 - 889.

Oliveira, S. M., Ribeiro, C. A., Cardoso, I., & Saraiva, M. J. (2011). Gender-dependent transthyretin modulation of brain amyloid-? Levels: Evidence from a mouse model of alzheimer's disease. Journal of Alzheimer's Disease, 27(2), 429 - 439.

Costa, R., Speretta, E., Crowther, D. C., & Cardoso, I. (2011). Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease. Journal of Biological Chemistry, 286(48), 41647 - 41655.

Saraiva, A. M., Cardoso, I., Pereira, M. C., Coelho, M. A. N., et al. (2010). Controlling amyloid-? peptide(1-42) oligomerization and toxicity by fluorinated nanoparticles. ChemBioChem, 11(13), 1905 - 1913.

Martinho, A., Gonçalves, I., Cardoso, I., Almeida, M. R., et al. (2010). Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin. FEBS Journal, 277(16), 3427 - 3436.

Saraiva, A. M., Cardoso, I., Saraiva, M. J., Tauer, K., et al. (2010). Randomization of Amyloid-?-Peptide(1-42) Conformation by Sulfonated and Sulfated Nanoparticles Reduces Aggregation and Cytotoxicity. Macromolecular Bioscience, 10(10), 1152 - 1163.

Cardoso, I., Martins, D., Ribeiro, T., Merlini, G., & Saraiva, M. J. (2010). Synergy of combined Doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: Studies in FAP mouse models. Journal of Translational Medicine, 8.

Ferreira, N., Cardoso, I., Domingues, M. R., Vitorino, R., et al. (2009). Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity. FEBS Letters, 583(22), 3569 - 3576.

Rocha, S., Cardoso, I., Börner, H., Pereira, M. C., et al. (2009). Design and biological activity of ?-sheet breaker peptide conjugates. Biochemical and Biophysical Research Communications, 380(2), 397 - 401.

Santos, S. D., Costa, R., Teixeira, P. F., Gottesman, M., et al. (2008). Amyloidogenic properties of transthyretin-like protein (TLP) from Escherichia coli. FEBS Letters, 582(19), 2893 - 2898.

Cardoso, I., Brito, M., & Saraiva, M. J. (2008). Extracellular matrix markers for disease progression and follow-up of therapies in familial amyloid polyneuropathy V30M TTR-related. Disease Markers, 25(1), 37 - 47.

Costa, R., Gonçalves, A., Saraiva, M. J., & Cardoso, I. (2008). Transthyretin binding to A-Beta peptide - Impact on A-Beta fibrillogenesis and toxicity. FEBS Letters, 582(6), 936 - 942.

Costa, R., Ferreira-Da-Silva, F., Saraiva, M. J., & Cardoso, I. (2008). Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: A mechanism sensitive to the kunitz protease inhibitor. PLoS ONE, 3(8).

Cardoso, I., Almeida, M. R., Ferreira, N., Arsequell, G., et al. (2007). Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: Relevance in drug design. Biochemical Journal, 408(1), 131 - 138.

Santos, S. D., Cardoso, I., Magalhães, J., & Saraiva, M. J. (2007). Impairment of the ubiquitin-proteasome system associated with extracellular transthyretin aggregates in familial amyloidotic polyneuropathy. Journal of Pathology, 213(2), 200 - 209.

Sousa, J. C., Cardoso, I., Marques, F., Saraiva, M. J., & Palha, J. A. (2007). Transthyretin and Alzheimer's disease: Where in the brain?. Neurobiology of Aging, 28(5), 713 - 718.

Monteiro, F. A., Sousa, M. M., Cardoso, I., Do Amaral, J. B., et al. (2006). Activation of ERK1/2 MAP kinases in familial amyloidotic polyneuropathy. Journal of Neurochemistry, 97(1), 151 - 161.

Cardoso, I., & Saraiva, M. J. (2006). Doxycycline disrupts transthyretin amyloid: Evidence from studies in a FAP transgenic mice model. FASEB Journal, 20(2), 234 - 239.

Monteiro, F. A., Cardoso, I., Sousa, M. M., & Saraiva, M. J. (2006). In vitro inhibition of transthyretin aggregate-induced cytotoxicity by full and peptide derived forms of the soluble receptor for advanced glycation end products (RAGE). FEBS Letters, 580(14), 3451 - 3456.

Almeida, M. R., Gales, L., Damas, A. M., Cardoso, I., & Saraiva, M. J. (2005). Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses. Current Drug Targets: CNS and Neurological Disorders, 4(5), 587 - 596.

Saraiva, M. J., Sousa, M. M., Cardoso, I., & Fernandes, R. (2004). Familial amyloidotic polyneuropathy: Protein aggregation in the peripheral nervous system. Journal of Molecular Neuroscience, 23(1-2), 35 - 40.

Almeida, M. R., Macedo, B., Cardoso, I., Alves, I., et al. (2004). Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative. Biochemical Journal, 381(2), 351 - 356.