%0 Journal Article %J Biochemical Journal %D 2017 %T A role for prolyl isomerase PIN1 in the phosphorylation-dependent modulation of PRRXL1 function %A Soares-Dos-Reis, R. %A Sofia Pessoa, A. %A Dias, A.F. %A Falcão, M. %A Matos, M.R. %A Vitorino, R. %A Monteiro, F.A. %A Lima, D. %A Reguenga, C. %B Biochemical Journal %V 474 %P 683 - 697 %8 2017 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014580896&doi=10.1042%2fBCJ20160560&partnerID=40&md5=4b11fcd0efe4a570f8392ec350562806 %N 5 %0 Journal Article %J Frontiers in Computational Neuroscience %D 2016 %T Analysis of nociceptive information encoded in the temporal discharge patterns of cutaneous C-fibers %A Cho, K. %A Jang, J.H. %A Kim, S.-P. %A Lee, S.H. %A Chung, S.-C. %A Kim, I.Y. %A Jang, D.P. %A Jung, S.J. %A Korogod, S.M. %A Lima, D. %A Lee, S. %B Frontiers in Computational Neuroscience %V 10 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84998538578&doi=10.3389%2ffncom.2016.00118&partnerID=40&md5=a82d81ba2b9c337cf3ae814ed001d612 %N NOV %0 Journal Article %J Pain %D 2016 %T Increased fronto-hippocampal connectivity in the Prrxl1 knockout mouse model of congenital hypoalgesia %A Monteiro, C. %A Cardoso-Cruz, H. %A Matos, M. %A Dourado, M. %A Lima, D. %A Galhardo, V. %B Pain %V 157 %P 2045 - 2056 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984605078&doi=10.1097%2fj.pain.0000000000000611&partnerID=40&md5=ec1dc67b295542df96a7b3b565f28017 %N 9 %0 Journal Article %J European Journal of Neuroscience %D 2016 %T Zinc finger transcription factor Casz1 expression is regulated by homeodomain transcription factor Prrxl1 in embryonic spinal dorsal horn late-born excitatory interneurons %A Monteiro, C.B. %A Midão, L. %A Rebelo, S. %A Reguenga, C. %A Lima, D. %A Monteiro, F.A. %B European Journal of Neuroscience %V 43 %P 1449 - 1459 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84960977317&doi=10.1111%2fejn.13214&partnerID=40&md5=2d38a7e329b05f0b6ff9e810b11c1238 %N 11 %0 Journal Article %J Journal of Neurophysiology %D 2014 %T The pronociceptive dorsal reticular nucleus contains mostly tonic neurons and shows a high prevalence of spontaneous activity in block preparation %A Sousa, M. %A Szucs, P. %A Lima, D. %A Aguiar, P. %B Journal of Neurophysiology %V 111 %P 1507 - 1518 %8 2014 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84900810824&partnerID=40&md5=521467d9d5b322ce1ff7842cbd036bc8 %N 7 %0 Journal Article %J Journal of Neuroscience %D 2013 %T Impaired spatial memory performance in a rat model of neuropathic pain is associated with reduced hippocampus-prefrontal cortex connectivity %A Cardoso-Cruz, H. %A Lima, D. %A Galhardo, V. %B Journal of Neuroscience %V 33 %P 2465 - 2480 %8 2013/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84873294842&partnerID=40&md5=a8fb45994915c5cd0c7c34aee1966b0f %N 6 %0 Journal Article %J Pain %D 2013 %T Prefrontal cortex and mediodorsal thalamus reduced connectivity is associated with spatial working memory impairment in rats with inflammatory pain %A Cardoso-Cruz, H. %A Sousa, M. %A Vieira, J.B. %A Lima, D. %A Galhardo, V. %B Pain %V 154 %P 2397 - 2406 %8 2013 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84886313692&partnerID=40&md5=f02b5c22b09491479fadd05fe7d06dcf %N 11 %0 Journal Article %J Pain %D 2012 %T Inflammatory pain disrupts the orbitofrontal neuronal activity and risk-assessment performance in a rodent decision-making task %A Pais-Vieira, M. %A Aguiar, P. %A Lima, D. %A Galhardo, V. %B Pain %V 153 %P 1625 - 1635 %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84863720383&partnerID=40&md5=339215bea11209e8b0b73d4a01512fb9 %N 8 %0 Journal Article %J Cortex %D 2011 %T Accuracy, reliability, validity and limitations of functional and structural magnetic resonance imaging data %A Seixas, D. %A Lima, D. %B Cortex %V 47 %P 1266 - 1269 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-80054055431&partnerID=40&md5=19d97b49dbb39e5b29e86c4daa2739c9 %N 10 %0 Journal Article %J Frontiers in Integrative Neuroscience %D 2011 %T Dynamics of circadian thalamocortical flow of information during a peripheral neuropathic pain condition %A Cardoso-Cruz, H. %A Sameshima, K. %A Lima, D. %A Galhardo, V. %B Frontiers in Integrative Neuroscience %V 5 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-82255171062&partnerID=40&md5=d54aaad91ac394f061563f9c299ffc25 %0 Journal Article %J European Journal of Neuroscience %D 2011 %T Instability of spatial encoding by CA1 hippocampal place cells after peripheral nerve injury %A Cardoso-Cruz, H. %A Lima, D. %A Galhardo, V. %B European Journal of Neuroscience %V 33 %P 2255 - 2264 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-80955180955&partnerID=40&md5=192c432fb7985e1448c9ec7d2732cdd7 %N 12 %0 Journal Article %J Sinapse %D 2011 %T Pain Research Group of the Faculty of Medicine University of Porto/IBMC (Institute of Molecular and Celular Biology) %A Lima, D. %B Sinapse %V 11 %P 36 - 39 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-80052903009&partnerID=40&md5=eb6aefcaec74476b8ae246cf9016b4e3 %N SUPPL. %0 Journal Article %J European Journal of Pain %D 2011 %T Postnatal expression of the homeobox gene Prrxl1 (Drg11) is increased in inflammatory but not neuropathic pain %A Monteiro, C. %A Rebelo, S. %A Galhardo, V. %A Reguenga, C. %A Lima, D. %B European Journal of Pain %V 15 %P 477 - 481 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-79956137374&partnerID=40&md5=c78e435b13845d79057a4cfcffaccaa6 %N 5 %0 Journal Article %J European Journal of Pain %D 2011 %T Reversal of inflammatory pain by HSV-1-mediated overexpression of enkephalin in the caudal ventrolateral medulla %A Martins, I. %A Cabral, L. %A Pinto, A. %A Wilson, S.P. %A Lima, D. %A Tavares, I. %B European Journal of Pain %V 15 %P 1008 - 1014 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-80455164738&partnerID=40&md5=bde7b980b8fc0a6c2c5782866a1dc8bd %N 10 %0 Journal Article %J Journal of Comparative Neurology %D 2010 %T Local axon collaterals of lamina I projection neurons in the spinal cord of young rats %A Szucs, P. %A Luz, L.L. %A Lima, D. %A Safronov, B.V. %B Journal of Comparative Neurology %V 518 %P 2645 - 2665 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-77954566628&partnerID=40&md5=f04e3b197c8e81f55c3aba2fa842792d %N 14 %0 Journal Article %J Journal of Neuroscience %D 2010 %T Multisegmental Aδ- and C-fiber input to neurons in lamina I and the lateral spinal nucleus %A Pinto, V. %A Szucs, P. %A Lima, D. %A Safronov, B.V. %B Journal of Neuroscience %V 30 %P 2384 - 2395 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-76649088934&partnerID=40&md5=e8cda0f4a5ba6e7db6ea8fd281644b06 %N 6 %0 Journal Article %J Journal of Neurophysiology %D 2010 %T NMDA channels together with L-type calcium currents and calcium-activated nonspecific cationic currents are sufficient to generate windup in WDR neurons %A Aguiar, P. %A Sousa, M. %A Lima, D. %B Journal of Neurophysiology %V 104 %P 1155 - 1166 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-77955972258&partnerID=40&md5=bf9c70363a432bcc66b6242c2cd1b3fd %N 2 %0 Journal Article %J Developmental Dynamics %D 2010 %T Prrxl1 is required for the generation of a subset of nociceptive glutamatergic superficial spinal dorsal horn neurons %A Rebelo, S. %A Reguenga, C. %A Lopes, C. %A Lima, D. %B Developmental Dynamics %V 239 %P 1684 - 1694 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-77952722318&partnerID=40&md5=9b4ffa3b6f0f96d627aa13016970c873 %N 6 %0 Journal Article %J Neuroscience %D 2009 %T Cognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain %A Pais-Vieira, M. %A Mendes-Pinto, M.M. %A Lima, D. %A Galhardo, V. %B Neuroscience %V 161 %P 671 - 679 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-67349243662&partnerID=40&md5=066a0947b53c7dacab1d96c3eaf4b75f %N 3 %0 Journal Article %J International Journal of Developmental Biology %D 2009 %T Expression of a Prrxl1 alternative splice variant during the development of the mouse nociceptive system %A Rebelo, S. %A Lopes, C. %A Lima, D. %A Reguenga, C. %B International Journal of Developmental Biology %V 53 %P 1089 - 1095 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-70350026829&partnerID=40&md5=3656c314c934e84eaf631f159f8a4c4a %N 7 %0 Journal Article %J Neurobiology of Disease %D 2009 %T Neurophysiological, behavioral and morphological abnormalities in the Fabry knockout mice %A Rodrigues, L.G. %A Ferraz, M.J. %A Rodrigues, D. %A Pais-Vieira, M. %A Lima, D. %A Brady, R.O. %A Sousa, M.M. %A Sá-Miranda, M.C. %B Neurobiology of Disease %V 33 %P 48 - 56 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-57449094948&partnerID=40&md5=463e8f6d9d9cadac9c40c4901346c04a %N 1 %0 Journal Article %J Dor na esclerose múltipla: Caracterização de uma população Portuguesa de 85 doentesActa Medica Portuguesa %D 2009 %T Pain in multiple sclerosis: Characterization of a Portuguese population of 85 patients %A Seixas, D. %A Galhardo, V. %A Sá, M.J. %A Guimarães, J. %A Lima, D. %B Dor na esclerose múltipla: Caracterização de uma população Portuguesa de 85 doentesActa Medica Portuguesa %V 22 %P 233 - 240 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-70449730928&partnerID=40&md5=5cf7776b232c74976326d7a7e695a59a %N 3 %0 Journal Article %J Neuroscience Letters %D 2009 %T Sustained attention deficits in rats with chronic inflammatory pain %A Pais-Vieira, M. %A Lima, D. %A Galhardo, V. %B Neuroscience Letters %V 463 %P 98 - 102 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-68149164741&partnerID=40&md5=14ab0d6d13a0cba52217c1eca19cc6b6 %N 1 %0 Journal Article %J PLoS ONE %D 2009 %T Transmission efficacy and plasticity in glutamatergic synapses formed by excitatory interneurons of the substantia gelatinosa in the rat spinal cord %A Santos, S.F.A. %A Luz, L.L. %A Szucs, P. %A Lima, D. %A Derkach, V.A. %A Safronov, B.V. %B PLoS ONE %V 4 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-77951251897&partnerID=40&md5=dabc903290050a95e6a005a33c3016d8 %N 11 %0 Journal Article %J European Journal of Neuroscience %D 2008 %T Dynamic of migration of HSV-1 from a medullary pronociceptive centre: Antinociception by overexpression of the preproenkephalin transgene %A Martins, I. %A Pinto, M. %A Wilson, S.P. %A Lima, D. %A Tavares, I. %B European Journal of Neuroscience %V 28 %P 2075 - 2083 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-55949120169&partnerID=40&md5=1e32fff1d5944df9ace9ab6ac655aa46 %N 10 %0 Journal Article %J Molecular and Cellular Neuroscience %D 2008 %T Opioids modulate pain facilitation from the dorsal reticular nucleus %A Pinto, M. %A Castro, A.R. %A Tshudy, F. %A Wilson, S.P. %A Lima, D. %A Tavares, I. %B Molecular and Cellular Neuroscience %V 39 %P 508 - 518 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-56249149196&partnerID=40&md5=d5b65ab1dc8eb6bbe168373b7526fc3e %N 4 %0 Journal Article %J Journal of Comparative Neurology %D 2008 %T Participation of μ-opioid, GABAB, and NK1 receptors of major pain control medullary areas in pathways targeting the rat spinal cord: Implications for descending modulation of nociceptive transmission %A Pinto, M. %A Sousa, M. %A Lima, D. %A Tavares, I. %B Journal of Comparative Neurology %V 510 %P 175 - 187 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-50249092715&partnerID=40&md5=60eb5ef2b493f4f6ee00d359bbb2ca01 %N 2 %0 Journal Article %J Journal of Neuroscience %D 2008 %T Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons %A Xu, Y. %A Lopes, C. %A Qian, Y. %A Liu, Y. %A Cheng, L. %A Goulding, M. %A Turner, E.E. %A Lima, D. %A Ma, Q. %B Journal of Neuroscience %V 28 %P 4037 - 4046 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-43049176725&partnerID=40&md5=0450f53560f4cb702e52f3f8181d6786 %N 15 %0 Journal Article %J Developmental Dynamics %D 2007 %T DRG11 immunohistochemical expression during embryonic development in the mouse %A Rebelo, S. %A Reguenga, C. %A Osório, L. %A Pereira, C. %A Lopes, C. %A Lima, D. %B Developmental Dynamics %V 236 %P 2653 - 2660 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-34548837504&partnerID=40&md5=228fd595956c637ddcd3d246e6301719 %N 9 %0 Journal Article %J Journal of Anatomy %D 2007 %T From neuroanatomy to gene therapy: Searching for new ways to manipulate the supraspinal endogenous pain modulatory system %A Tavares, I. %A Lima, D. %B Journal of Anatomy %V 211 %P 261 - 268 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-34548020294&partnerID=40&md5=0a5b136a7ac38a8a3bbccd0676d4a88d %N 2 %0 Journal Article %J Neuroscience %D 2007 %T Neuronal activation at the spinal cord and medullary pain control centers after joint stimulation: A c-fos study in acute and chronic articular inflammation %A Pinto, M. %A Lima, D. %A Tavares, I. %B Neuroscience %V 147 %P 1076 - 1089 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-34547118578&partnerID=40&md5=3015dcf47a16ad95dc9c8b984b4a7927 %N 4 %0 Journal Article %J Neuroscience %D 2007 %T Orbitofrontal cortex lesions disrupt risk assessment in a novel serial decision-making task for rats %A Pais-Vieira, M. %A Lima, D. %A Galhardo, V. %B Neuroscience %V 145 %P 225 - 231 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33846872787&partnerID=40&md5=3766a8a75fd46fbc695e9e1a3fdaadf2 %N 1 %0 Journal Article %J Neuroscience Letters %D 2006 %T Correlation of noxious evoked c-fos expression in areas of the somatosensory system during chronic pain: Involvement of spino-medullary and intra-medullary connections %A Pinto, M. %A Lima, D. %A Tavares, I. %B Neuroscience Letters %V 409 %P 100 - 105 %8 2006/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33750378060&partnerID=40&md5=84e8f947c610ab3b53fb3c61c62ad441 %N 2 %0 Journal Article %J Brain Research Bulletin %D 2006 %T Differential expression of NK1 and GABAB receptors in spinal neurones projecting to antinociceptive or pronociceptive medullary centres %A Castro, A.R. %A Morgado, C. %A Lima, D. %A Tavares, I. %B Brain Research Bulletin %V 69 %P 266 - 275 %8 2006/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33645061252&partnerID=40&md5=86cc606f5c88e5ecd3a80a40a5c84b10 %N 3 %0 Journal Article %J Molecular and Cellular Neuroscience %D 2006 %T Involvement of DRG11 in the development of the primary afferent nociceptive system %A Rebelo, S. %A Chen, Z.-F. %A Anderson, D.J. %A Lima, D. %B Molecular and Cellular Neuroscience %V 33 %P 236 - 246 %8 2006/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33750624134&partnerID=40&md5=5583bed168c4bd7fec7f91159072c038 %N 3 %0 Journal Article %J Neuroscience %D 2006 %T Secondary hyperalgesia in the monoarthritic rat is mediated by GABAB and NK1 receptors of spinal dorsal horn neurons: A behavior and c-fos study %A Castro, A.R. %A Pinto, M. %A Lima, D. %A Tavares, I. %B Neuroscience %V 141 %P 2087 - 2095 %8 2006/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33747161263&partnerID=40&md5=a18a738c49a2a6eed50c76fb9fc20e98 %N 4 %0 Journal Article %J Neuroscience Letters %D 2006 %T Switching-on and -off of bistable spontaneous discharges in rat spinal deep dorsal horn neurons %A Monteiro, C. %A Lima, D. %A Galhardo, V. %B Neuroscience Letters %V 398 %P 258 - 263 %8 2006/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33646381137&partnerID=40&md5=62d23ace607f8cd285ef0f43b1dbc5f9 %N 3 %0 Journal Article %J Neuroscience %D 2005 %T Imbalance between the expression of NK1 and GABAB receptors in nociceptive spinal neurons during secondary hyperalgesia: A c-Fos study in the monoarthritic rat %A Castro, A.R. %A Pinto, M. %A Lima, D. %A Tavares, I. %B Neuroscience %V 132 %P 905 - 916 %8 2005/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-18044366195&partnerID=40&md5=369d9a15878447ac480833d07774c5f4 %N 4 %0 Journal Article %J Brain Research %D 2004 %T Nociceptive spinal neurons expressing NK1 and GABAB receptors are located in lamina I %A Castro, A.R. %A Pinto, M. %A Lima, D. %A Tavares, I. %B Brain Research %V 1003 %P 77 - 85 %8 2004/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-1542298862&partnerID=40&md5=7c921c7a1eeaf335705477c98da58bcd %N 1-2