Innate IFN-γ-Producing cells developing in the absence of IL-2 receptor common γ-chain - Resende, M.; Cardoso, M.S.; Ribeiro, A.R.; Flórido, M.; Borges, M.; Gil Castro, A.; Alves, N.L.; Cooper, A.M.; Appelberg, R. (Journal of Immunology, 2017)

Type i IFN inhibits alternative macrophage activation during mycobacterium tuberculosis infection and leads to enhanced protection in the absence of IFN-γ signaling - Moreira-Teixeira, L.; Sousa, J.; McNab, F.W.; Torrado, E.; Cardoso, F.; Machado, H.; Castro, F.; Cardoso, V.; Gaifem, J.; Wu, X.; Appelberg, R.; Castro, A.G.; et al. (Journal of Immunology, 2016)

BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4+IL-17+TNF+IL-2+ T cells - Cruz, A.; Torrado, E.; Carmona, J.; Fraga, A.G.; Costa, P.; Rodrigues, F.; Appelberg, R.; Correia-Neves, M.; Cooper, A.M.; Saraiva, M.; Pedrosa, J.; Castro, A.G. (Vaccine, 2015)

Lack of the transcription factor hypoxia-inducible factor 1α (HIF- 1α) in macrophages accelerates the necrosis of Mycobacterium avium-induced granulomas - Cardoso, M.S.; Silva, T.M.; Resende, M.; Appelberg, R.; Borges, M. (Infection and Immunity, 2015)

The Warburg effect in mycobacterial granulomas is dependent on the recruitment and activation of macrophages by interferon-γ - Appelberg, R.; Moreira, D.; Barreira-Silva, P.; Borges, M.; Silva, L.; Dinis-Oliveira, R. J.; Resende, M.; Correia-Neves, M.; Jordan, M. B.; Ferreira, N.C.; Abrunhosa, A.J.; Silvestre, R. (Immunology, 2015)

Heme catabolism by heme oxygenase-1 confers host resistance to Mycobacterium infection - Silva-Gomes, S.; Appelberg, R.; Larsen, R.; Soares, M.P.; Gomes, M.S. (Infection and Immunity, 2013)

Iron Overload Favors the Elimination of Leishmania infantum from Mouse Tissues through Interaction with Reactive Oxygen and Nitrogen Species - Vale-Costa, S.; Gomes-Pereira, S.; Teixeira, C.M.; Rosa, G.; Rodrigues, P.N.; Tomás, A.; Appelberg, R.; Gomes, M.S. (PLoS Neglected Tropical Diseases, 2013)

Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in experimental animal models of infection and have minimal impact on in vitro inflammatory responses - Afonso-Barroso, A.; Clark, S. O.; Williams, A.; Rosa, G.T.; Nóbrega, C.; Silva-Gomes, S.; Vale-Costa, S.; Ummels, R.; Stoker, N.; Movahedzadeh, F.; van der Ley, P.; Sloots, A.; et al. (Cellular Microbiology, 2013)

Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in experimental animal models of infection and have minimal impact on in vitro inflammatory responses - Afonso-Barroso, A.; Clark, S. O.; Williams, A.; Rosa, G.T.; Nóbrega, C.; Silva-Gomes, S.; Vale-Costa, S.; Ummels, R.; Stoker, N.; Movahedzadeh, F.; van der Ley, P.; Sloots, A.; et al. (Cellular Microbiology, 2012)

Molecular and cellular mechanisms of Mycobacterium avium-induced thymic atrophy - Borges, M.; Barreira-Silva, P.; Flórido, M.; Jordan, M. B.; Correia-Neves, M.; Appelberg, R. (Journal of Immunology, 2012)

Cathelicidin is involved in the intracellular killing of mycobacteria in macrophages - Sonawane, A.; Santos, J.C.; Mishra, B.B.; Jena, P.; Progida, C.; Sorensen, O.E.; Gallo, R.; Appelberg, R.; Griffiths, G. (Cellular Microbiology, 2011)

The death-promoting molecule tumour necrosis factor-related apoptosis inducing ligand (TRAIL) is not required for the development of peripheral lymphopenia or granuloma necrosis during infection with virulent Mycobacterium avium - Borges, M.; Rosa, G.T.; Appelberg, R. (Clinical and Experimental Immunology, 2011)

Leishmania mitochondrial peroxiredoxin plays a crucial peroxidase-unrelated role during infection: Insight into its novel chaperone activity - Castro, H.; Teixeira, F.; Romao, S.; Santos, M.; Cruz, T.; Flórido, M.; Appelberg, R.; Oliveira, P.; Ferreira-Da-Silva, F.; Tomás, A.M. (PLoS Pathogens, 2011)

Macrophages from IBD patients exhibit defective tumour necrosis factor-α secretion but otherwise normal or augmented pro-inflammatory responses to infection - Campos, N.; Magro, F.; Castro, A.R.; Cabral, J.; Rodrigues, P.; Silva, R.; Appelberg, R.; Rodrigues, S.; Lopes, S.; Macedo, G.; Sarmento, A. (Immunobiology, 2011)

Mycobacteria-induced anaemia revisited: A molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin - Rodrigues, P.N.; Gomes, S.S.; Neves, J.V.; Gomes-Pereira, S.; Correia-Neves, M.; Nunes-Alves, C.; Stolte, J.; Sanchez, M.; Appelberg, R.; Muckenthaler, M.U.; Gomes, M.S. (Immunobiology, 2011)

Toll-like receptor 9 is required for full host resistance to Mycobacterium avium infection but plays no role in induction of Th1 responses - Carvalho, N.B.; Oliveira, F.S.; Durães, F.V.; de Almeida, L.A.; Flórido, M.; Prata, L.O.; Caliari, M.V.; Appelberg, R.; Oliveira, S.C. (Infection and Immunity, 2011)

Dissemination of mycobacteria to the thymus renders newly generated T cells tolerant to the invading pathogen - Nobrega, C.; Roque, S.; Nunes-Alves, C.; Coelho, A.; Medeiros, I.; Castro, A.G.; Appelberg, R.; Correia-Neves, M. (Journal of Immunology, 2010)

Identification of a new hexadentate iron chelator capable of restricting the intramacrophagic growth of Mycobacterium avium - Fernandes, S.S.; Nunes, A.; Gomes, A.R.; de Castro, B.; Hider, R.C.; Rangel, M.; Appelberg, R.; Gomes, M.S. (Microbes and Infection, 2010)

Constitutive expression of Bcl-2 in the haematopoietic compartment alters the metabolism of iron and increases resistance to mycobacterial infection - Flórido, M.; Borges, M.; Rodrigues, P.; Vale-Costa, S.; Salomé Gomes, M.; Appelberg, R. (Clinical and Experimental Immunology, 2009)

Delayed recruitment of lymphocytes into the lungs of CD30-deficient mice during aerogenic Mycobacterium avium infections - Flórido, M.; McColl, S.R.; Appelberg, R. (Immunobiology, 2009)

Engagement of Toll-like receptor 2 in mouse macrophages infected with Mycobacterium avium induces non-oxidative and TNF-independent anti-mycobacterial activity - Salomé Gomes, M.; Fernandes, S.S.; Cordeiro, J.V.; Gomes, S.S.; Vieira, A.; Appelberg, R. (European Journal of Immunology, 2008)

Increased susceptibility to Mycobacterium avium in hemochromatosis protein HFE-deficient mice - Gomes-Pereira, S.; Rodrigues, P.N.; Appelberg, R.; Gomes, M.S. (Infection and Immunity, 2008)

Characterization of the deregulated immune activation occurring at late stages of mycobacterial infection in TNF-deficient mice - Flórido, M.; Appelberg, R. (Journal of Immunology, 2007)

Design, synthesis, biochemical evaluation and antimycobacterial action of phosphonate inhibitors of antigen 85C, a crucial enzyme involved in biosynthesis of the mycobacterial cell wall - Gobec, S.; Plantan, I.; Mravljak, J.; Švajger, U.; Wilson, R.A.; Besra, G.S.; Soares, S.L.; Appelberg, R.; Kikelj, D. (European Journal of Medicinal Chemistry, 2007)

The effect of the host's iron status on tuberculosis - Boelaert, J.R.; Vandecasteele, S.J.; Appelberg, R.; Gordeuk, V.R. (Journal of Infectious Diseases, 2007)

IL-10 underlies distinct susceptibility of BALB/c and C57BL/6 mice to Mycobacterium avium infection and influences efficacy of antibiotic therapy - Roque, S.; Nobrega, C.; Appelberg, R.; Correia-Neves, M. (Journal of Immunology, 2007)

Neutrophils and intracellular pathogens: beyond phagocytosis and killing - Appelberg, R. (Trends in Microbiology, 2007)

The thymus as a target for mycobacterial infections - Nobrega, C.; Cardona, P.-J.; Roque, S.; Pinto do Ó, P.; Appelberg, R.; Correia-Neves, M. (Microbes and Infection, 2007)

Virulence of Mycobacterium avium in mice does not correlate with resistance to nitric oxide - Lousada, S.; Flórido, M.; Appelberg, R. (Microbial Pathogenesis, 2007)

Genetic control of immune-mediated necrosis of Mycobacterium avium granulomas - Flórido, M.; Appelberg, R. (Immunology, 2006)

Macrophage nutriprive antimicrobial mechanisms - Appelberg, R. (Journal of Leukocyte Biology, 2006)

Pathogenesis of Mycobacterium avium infection: Typical responses to an atypical Mycobacterium? - Appelberg, R. (Immunologic Research, 2006)

Regulation of granuloma fibrosis by nitric oxide during Mycobacterium avium experimental infection - Lousada, S.; Flórido, M.; Appelberg, R. (International Journal of Experimental Pathology, 2006)

Gamma interferon-induced T-cell loss in virulent Mycobacterium avium infection - Flórido, M.; Pearl, J.E.; Solache, A.; Borges, M.; Haynes, L.; Cooper, A.M.; Appelberg, R. (Infection and Immunity, 2005)

CD40 is required for the optimal induction of protective immunity to Mycobacterium avium - Flórido, M.; Gonçalves, A.S.; Gomes, M.S.; Appelberg, R. (Immunology, 2004)

Contribution of CD30/CD153 but not of CD27/CD70, CD134/OX40L, or CD137/4-1BBL to the optimal induction of protective immunity to Mycobacterium avium - Flórido, M.; Borges, M.; Yagita, H.; Appelberg, R. (Journal of Leukocyte Biology, 2004)

Granuloma necrosis during Mycobacterium avium infection does not require tumor necrosis factor - Flórido, M.; Appelberg, R. (Infection and Immunity, 2004)

Induction of Mycobacterium avium growth restriction and inhibition of phagosome-endosome interactions during macrophage during macrophage activation and apoptosis induction by picolinic acid plus IFNγ - Pais, T.F.; Appelberg, R. (Microbiology, 2004)

Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium - Gomes, M.S.; Flórido, M.; Cordeiro, J.V.; Teixeira, C.M.; Takeuchi, O.; Akira, S.; Appelberg, R. (Immunology, 2004)