%0 Journal Article %J Journal of Immunology %D 2017 %T Innate IFN-γ-Producing cells developing in the absence of IL-2 receptor common γ-chain %A Resende, M. %A Cardoso, M.S. %A Ribeiro, A.R. %A Flórido, M. %A Borges, M. %A Gil Castro, A. %A Alves, N.L. %A Cooper, A.M. %A Appelberg, R. %B Journal of Immunology %V 199 %P 1429 - 1439 %8 2017 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-85027298608&doi=10.4049%2fjimmunol.1601701&partnerID=40&md5=9a8ad502547ca660bbcec14a73955ec9 %N 4 %0 Journal Article %J Journal of Immunology %D 2016 %T Type i IFN inhibits alternative macrophage activation during mycobacterium tuberculosis infection and leads to enhanced protection in the absence of IFN-γ signaling %A Moreira-Teixeira, L. %A Sousa, J. %A McNab, F.W. %A Torrado, E. %A Cardoso, F. %A Machado, H. %A Castro, F. %A Cardoso, V. %A Gaifem, J. %A Wu, X. %A Appelberg, R. %A Castro, A.G. %A O'Garra, A. %A Saraiva, M. %B Journal of Immunology %V 197 %P 4714 - 4726 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-85002328285&doi=10.4049%2fjimmunol.1600584&partnerID=40&md5=c023b2d644e065df9a81bd76e86a04cc %N 12 %0 Journal Article %J Vaccine %D 2015 %T BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4+IL-17+TNF+IL-2+ T cells %A Cruz, A. %A Torrado, E. %A Carmona, J. %A Fraga, A.G. %A Costa, P. %A Rodrigues, F. %A Appelberg, R. %A Correia-Neves, M. %A Cooper, A.M. %A Saraiva, M. %A Pedrosa, J. %A Castro, A.G. %B Vaccine %V 33 %P 85 - 91 %8 2015 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84919360521&partnerID=40&md5=7dc924fd77e380179495ca40f31bc4b7 %N 1 %0 Journal Article %J Infection and Immunity %D 2015 %T Lack of the transcription factor hypoxia-inducible factor 1α (HIF- 1α) in macrophages accelerates the necrosis of Mycobacterium avium-induced granulomas %A Cardoso, M.S. %A Silva, T.M. %A Resende, M. %A Appelberg, R. %A Borges, M. %B Infection and Immunity %V 83 %P 3534 - 3544 %8 2015 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84939546765&partnerID=40&md5=0ecd79a4563b757340e9f6584eeca2ed %N 9 %0 Journal Article %J Immunology %D 2015 %T The Warburg effect in mycobacterial granulomas is dependent on the recruitment and activation of macrophages by interferon-γ %A Appelberg, R. %A Moreira, D. %A Barreira-Silva, P. %A Borges, M. %A Silva, L. %A Dinis-Oliveira, R. J. %A Resende, M. %A Correia-Neves, M. %A Jordan, M. B. %A Ferreira, N.C. %A Abrunhosa, A.J. %A Silvestre, R. %B Immunology %V 145 %P 498 - 507 %8 2015 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84936175105&partnerID=40&md5=efaa158bf03ca6af0fa4a37c5f4f2cfe %N 4 %0 Journal Article %J Infection and Immunity %D 2013 %T Heme catabolism by heme oxygenase-1 confers host resistance to Mycobacterium infection %A Silva-Gomes, S. %A Appelberg, R. %A Larsen, R. %A Soares, M.P. %A Gomes, M.S. %B Infection and Immunity %V 81 %P 2536 - 2545 %8 2013 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84879426573&partnerID=40&md5=08ce29789a4be0c8355f0dd95e9153a0 %N 7 %0 Journal Article %J PLoS Neglected Tropical Diseases %D 2013 %T Iron Overload Favors the Elimination of Leishmania infantum from Mouse Tissues through Interaction with Reactive Oxygen and Nitrogen Species %A Vale-Costa, S. %A Gomes-Pereira, S. %A Teixeira, C.M. %A Rosa, G. %A Rodrigues, P.N. %A Tomás, A. %A Appelberg, R. %A Gomes, M.S. %B PLoS Neglected Tropical Diseases %V 7 %8 2013/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84874764417&partnerID=40&md5=e8d3a65ff384e9df9230220386504405 %N 2 %0 Journal Article %J Cellular Microbiology %D 2013 %T Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in experimental animal models of infection and have minimal impact on in vitro inflammatory responses %A Afonso-Barroso, A. %A Clark, S. O. %A Williams, A. %A Rosa, G.T. %A Nóbrega, C. %A Silva-Gomes, S. %A Vale-Costa, S. %A Ummels, R. %A Stoker, N. %A Movahedzadeh, F. %A van der Ley, P. %A Sloots, A. %A Cot, M. %A Appelmelk, B. J. %A Puzo, G. %A Nigou, J. %A Geurtsen, J. %A Appelberg, R. %B Cellular Microbiology %V 15 %P 660 - 674 %8 2013 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84874977321&partnerID=40&md5=f69a630f8d85f71ce65d0ec518df74c8 %N 4 %0 Generic %D 2012 %T Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in experimental animal models of infection and have minimal impact on in vitro inflammatory responses %A Afonso-Barroso, A. %A Clark, S. O. %A Williams, A. %A Rosa, G.T. %A Nóbrega, C. %A Silva-Gomes, S. %A Vale-Costa, S. %A Ummels, R. %A Stoker, N. %A Movahedzadeh, F. %A van der Ley, P. %A Sloots, A. %A Cot, M. %A Appelmelk, B. J. %A Puzo, G. %A Nigou, J. %A Geurtsen, J. %A Appelberg, R. %B Cellular Microbiology %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84869886643&partnerID=40&md5=a8706e6711d67547109ade23ea3b4e8d %0 Journal Article %J Journal of Immunology %D 2012 %T Molecular and cellular mechanisms of Mycobacterium avium-induced thymic atrophy %A Borges, M. %A Barreira-Silva, P. %A Flórido, M. %A Jordan, M. B. %A Correia-Neves, M. %A Appelberg, R. %B Journal of Immunology %V 189 %P 3600 - 3608 %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84866527721&partnerID=40&md5=eaaac9bea4fc4df6733141aad2d4b5a5 %N 7 %0 Journal Article %J Cellular Microbiology %D 2011 %T Cathelicidin is involved in the intracellular killing of mycobacteria in macrophages %A Sonawane, A. %A Santos, J.C. %A Mishra, B.B. %A Jena, P. %A Progida, C. %A Sorensen, O.E. %A Gallo, R. %A Appelberg, R. %A Griffiths, G. %B Cellular Microbiology %V 13 %P 1601 - 1617 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-80052794411&partnerID=40&md5=f230a8b68cde88c1548d06c448cebe3f %N 10 %0 Journal Article %J Clinical and Experimental Immunology %D 2011 %T The death-promoting molecule tumour necrosis factor-related apoptosis inducing ligand (TRAIL) is not required for the development of peripheral lymphopenia or granuloma necrosis during infection with virulent Mycobacterium avium %A Borges, M. %A Rosa, G.T. %A Appelberg, R. %B Clinical and Experimental Immunology %V 164 %P 407 - 416 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-79955485316&partnerID=40&md5=8eab40af4915e997a3043ad48819845f %N 3 %0 Journal Article %J PLoS Pathogens %D 2011 %T Leishmania mitochondrial peroxiredoxin plays a crucial peroxidase-unrelated role during infection: Insight into its novel chaperone activity %A Castro, H. %A Teixeira, F. %A Romao, S. %A Santos, M. %A Cruz, T. %A Flórido, M. %A Appelberg, R. %A Oliveira, P. %A Ferreira-Da-Silva, F. %A Tomás, A.M. %B PLoS Pathogens %V 7 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-80055096383&partnerID=40&md5=8bd03c5f9e7d3f02f8423e638a72ed65 %N 10 %0 Journal Article %J Immunobiology %D 2011 %T Macrophages from IBD patients exhibit defective tumour necrosis factor-α secretion but otherwise normal or augmented pro-inflammatory responses to infection %A Campos, N. %A Magro, F. %A Castro, A.R. %A Cabral, J. %A Rodrigues, P. %A Silva, R. %A Appelberg, R. %A Rodrigues, S. %A Lopes, S. %A Macedo, G. %A Sarmento, A. %B Immunobiology %V 216 %P 961 - 970 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-79959492512&partnerID=40&md5=a7a0a1add5023bc3fbf05ee7e99f59f4 %N 8 %0 Journal Article %J Immunobiology %D 2011 %T Mycobacteria-induced anaemia revisited: A molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin %A Rodrigues, P.N. %A Gomes, S.S. %A Neves, J.V. %A Gomes-Pereira, S. %A Correia-Neves, M. %A Nunes-Alves, C. %A Stolte, J. %A Sanchez, M. %A Appelberg, R. %A Muckenthaler, M.U. %A Gomes, M.S. %B Immunobiology %V 216 %P 1127 - 1134 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-80052101945&partnerID=40&md5=fa1f865d95a1dbada9ca0886ef647956 %N 10 %0 Journal Article %J Infection and Immunity %D 2011 %T Toll-like receptor 9 is required for full host resistance to Mycobacterium avium infection but plays no role in induction of Th1 responses %A Carvalho, N.B. %A Oliveira, F.S. %A Durães, F.V. %A de Almeida, L.A. %A Flórido, M. %A Prata, L.O. %A Caliari, M.V. %A Appelberg, R. %A Oliveira, S.C. %B Infection and Immunity %V 79 %P 1638 - 1646 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-79953323282&partnerID=40&md5=b197ccd960d8600a7622347cf6a99b45 %N 4 %0 Journal Article %J Journal of Immunology %D 2010 %T Dissemination of mycobacteria to the thymus renders newly generated T cells tolerant to the invading pathogen %A Nobrega, C. %A Roque, S. %A Nunes-Alves, C. %A Coelho, A. %A Medeiros, I. %A Castro, A.G. %A Appelberg, R. %A Correia-Neves, M. %B Journal of Immunology %V 184 %P 351 - 358 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-73949157248&partnerID=40&md5=97211b0ba74cc6727c7f0cc2d868cae0 %N 1 %0 Journal Article %J Microbes and Infection %D 2010 %T Identification of a new hexadentate iron chelator capable of restricting the intramacrophagic growth of Mycobacterium avium %A Fernandes, S.S. %A Nunes, A. %A Gomes, A.R. %A de Castro, B. %A Hider, R.C. %A Rangel, M. %A Appelberg, R. %A Gomes, M.S. %B Microbes and Infection %V 12 %P 287 - 294 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-77649274461&partnerID=40&md5=993c8659de3f9b654df1616fbabb3a6c %N 4 %0 Journal Article %J Clinical and Experimental Immunology %D 2009 %T Constitutive expression of Bcl-2 in the haematopoietic compartment alters the metabolism of iron and increases resistance to mycobacterial infection %A Flórido, M. %A Borges, M. %A Rodrigues, P. %A Vale-Costa, S. %A Salomé Gomes, M. %A Appelberg, R. %B Clinical and Experimental Immunology %V 156 %P 61 - 68 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-61849113352&partnerID=40&md5=db65ed62d93b2287995ca6e25e86c6ab %N 1 %0 Journal Article %J Immunobiology %D 2009 %T Delayed recruitment of lymphocytes into the lungs of CD30-deficient mice during aerogenic Mycobacterium avium infections %A Flórido, M. %A McColl, S.R. %A Appelberg, R. %B Immunobiology %V 214 %P 643 - 652 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-67650077115&partnerID=40&md5=00483dd36ea2776e24ea7e1176e4fd95 %N 8 %0 Journal Article %J European Journal of Immunology %D 2008 %T Engagement of Toll-like receptor 2 in mouse macrophages infected with Mycobacterium avium induces non-oxidative and TNF-independent anti-mycobacterial activity %A Salomé Gomes, M. %A Fernandes, S.S. %A Cordeiro, J.V. %A Gomes, S.S. %A Vieira, A. %A Appelberg, R. %B European Journal of Immunology %V 38 %P 2180 - 2189 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-51149087071&partnerID=40&md5=f0c2996eb0c1ea54dfa3d35a73c32355 %N 8 %0 Journal Article %J Infection and Immunity %D 2008 %T Increased susceptibility to Mycobacterium avium in hemochromatosis protein HFE-deficient mice %A Gomes-Pereira, S. %A Rodrigues, P.N. %A Appelberg, R. %A Gomes, M.S. %B Infection and Immunity %V 76 %P 4713 - 4719 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-53649106524&partnerID=40&md5=857eeba3548f0305f6e159859dcd2873 %N 10 %0 Journal Article %J Journal of Immunology %D 2007 %T Characterization of the deregulated immune activation occurring at late stages of mycobacterial infection in TNF-deficient mice %A Flórido, M. %A Appelberg, R. %B Journal of Immunology %V 179 %P 7702 - 7708 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-38849194103&partnerID=40&md5=002f57a7dd3622bf7094795491670dd6 %N 11 %0 Journal Article %J European Journal of Medicinal Chemistry %D 2007 %T Design, synthesis, biochemical evaluation and antimycobacterial action of phosphonate inhibitors of antigen 85C, a crucial enzyme involved in biosynthesis of the mycobacterial cell wall %A Gobec, S. %A Plantan, I. %A Mravljak, J. %A Švajger, U. %A Wilson, R.A. %A Besra, G.S. %A Soares, S.L. %A Appelberg, R. %A Kikelj, D. %B European Journal of Medicinal Chemistry %V 42 %P 54 - 63 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33846690975&partnerID=40&md5=7b65af4fc2dba7cfd663c72faaf319e9 %N 1 %0 Journal Article %J Journal of Infectious Diseases %D 2007 %T The effect of the host's iron status on tuberculosis %A Boelaert, J.R. %A Vandecasteele, S.J. %A Appelberg, R. %A Gordeuk, V.R. %B Journal of Infectious Diseases %V 195 %P 1745 - 1753 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-34249863579&partnerID=40&md5=dc6b987bc828b1b6633f7e9eda53aa56 %N 12 %0 Journal Article %J Journal of Immunology %D 2007 %T IL-10 underlies distinct susceptibility of BALB/c and C57BL/6 mice to Mycobacterium avium infection and influences efficacy of antibiotic therapy %A Roque, S. %A Nobrega, C. %A Appelberg, R. %A Correia-Neves, M. %B Journal of Immunology %V 178 %P 8028 - 8035 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-34250173749&partnerID=40&md5=22f15e4cbbffa01b153845e2e1602dbe %N 12 %0 Journal Article %J Trends in Microbiology %D 2007 %T Neutrophils and intracellular pathogens: beyond phagocytosis and killing %A Appelberg, R. %B Trends in Microbiology %V 15 %P 87 - 92 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33846694050&partnerID=40&md5=ca411d152f00ad2fa50c98aa9fa840a8 %N 2 %0 Journal Article %J Microbes and Infection %D 2007 %T The thymus as a target for mycobacterial infections %A Nobrega, C. %A Cardona, P.-J. %A Roque, S. %A Pinto do Ó, P. %A Appelberg, R. %A Correia-Neves, M. %B Microbes and Infection %V 9 %P 1521 - 1529 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-36749031173&partnerID=40&md5=cd5cbff9d133d9d17b44e70586d6ad1c %N 14-15 %0 Journal Article %J Microbial Pathogenesis %D 2007 %T Virulence of Mycobacterium avium in mice does not correlate with resistance to nitric oxide %A Lousada, S. %A Flórido, M. %A Appelberg, R. %B Microbial Pathogenesis %V 43 %P 243 - 248 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-34548655034&partnerID=40&md5=26b7458fa52676313b482f137a059310 %N 5-6 %0 Journal Article %J Immunology %D 2006 %T Genetic control of immune-mediated necrosis of Mycobacterium avium granulomas %A Flórido, M. %A Appelberg, R. %B Immunology %V 118 %P 122 - 130 %8 2006/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33645801985&partnerID=40&md5=348d293694a5081d0cd6f39a4c1195d7 %N 1 %0 Journal Article %J Journal of Leukocyte Biology %D 2006 %T Macrophage nutriprive antimicrobial mechanisms %A Appelberg, R. %B Journal of Leukocyte Biology %V 79 %P 1117 - 1128 %8 2006/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33746881453&partnerID=40&md5=6d7c9263cb31e2f893786e789b5a08a2 %N 6 %0 Journal Article %J Immunologic Research %D 2006 %T Pathogenesis of Mycobacterium avium infection: Typical responses to an atypical Mycobacterium? %A Appelberg, R. %B Immunologic Research %V 35 %P 179 - 190 %8 2006/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33845894453&partnerID=40&md5=3fa29ffaeae0f31100baab42058d0d7e %N 3 %0 Journal Article %J International Journal of Experimental Pathology %D 2006 %T Regulation of granuloma fibrosis by nitric oxide during Mycobacterium avium experimental infection %A Lousada, S. %A Flórido, M. %A Appelberg, R. %B International Journal of Experimental Pathology %V 87 %P 307 - 315 %8 2006/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33745915521&partnerID=40&md5=72f0abc6d706b97e2ec13ea0a28ef882 %N 4 %0 Journal Article %J Infection and Immunity %D 2005 %T Gamma interferon-induced T-cell loss in virulent Mycobacterium avium infection %A Flórido, M. %A Pearl, J.E. %A Solache, A. %A Borges, M. %A Haynes, L. %A Cooper, A.M. %A Appelberg, R. %B Infection and Immunity %V 73 %P 3577 - 3586 %8 2005/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-19744376118&partnerID=40&md5=4fb502cda8a91cd65f7ae0b31d2455cf %N 6 %0 Journal Article %J Immunology %D 2004 %T CD40 is required for the optimal induction of protective immunity to Mycobacterium avium %A Flórido, M. %A Gonçalves, A.S. %A Gomes, M.S. %A Appelberg, R. %B Immunology %V 111 %P 323 - 327 %8 2004/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-1642297183&partnerID=40&md5=8b4792a648b17405f4401c6275781933 %N 3 %0 Journal Article %J Journal of Leukocyte Biology %D 2004 %T Contribution of CD30/CD153 but not of CD27/CD70, CD134/OX40L, or CD137/4-1BBL to the optimal induction of protective immunity to Mycobacterium avium %A Flórido, M. %A Borges, M. %A Yagita, H. %A Appelberg, R. %B Journal of Leukocyte Biology %V 76 %P 1039 - 1046 %8 2004/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-7644226724&partnerID=40&md5=d85b4dde25599adb297df6006a613531 %N 5 %0 Journal Article %J Infection and Immunity %D 2004 %T Granuloma necrosis during Mycobacterium avium infection does not require tumor necrosis factor %A Flórido, M. %A Appelberg, R. %B Infection and Immunity %V 72 %P 6139 - 6141 %8 2004/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-4644279510&partnerID=40&md5=714f26a2e17453131e2402957317cd59 %N 10 %0 Journal Article %J Microbiology %D 2004 %T Induction of Mycobacterium avium growth restriction and inhibition of phagosome-endosome interactions during macrophage during macrophage activation and apoptosis induction by picolinic acid plus IFNγ %A Pais, T.F. %A Appelberg, R. %B Microbiology %V 150 %P 1507 - 1518 %8 2004/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-2942627335&partnerID=40&md5=3ab30fee225e0b81daf57b002d88c457 %N 5 %0 Journal Article %J Immunology %D 2004 %T Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium %A Gomes, M.S. %A Flórido, M. %A Cordeiro, J.V. %A Teixeira, C.M. %A Takeuchi, O. %A Akira, S. %A Appelberg, R. %B Immunology %V 111 %P 179 - 185 %8 2004/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-0842265556&partnerID=40&md5=444c9ce3c9fe5a03ca0c90aa9dd95ef6 %N 2