%0 Journal Article %J Biomaterials %D 2017 %T BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury %A Lopes, C.D.F. %A Gonçalves, N.P. %A Gomes, C.P. %A Saraiva, M.J. %A Pêgo, A.P. %B Biomaterials %V 121 %P 83 - 96 %8 2017 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-85008958194&doi=10.1016%2fj.biomaterials.2016.12.025&partnerID=40&md5=c7e291f420cebaf3fba60b2680b0b3f5 %0 Journal Article %J PLoS ONE %D 2017 %T C1q ablation exacerbates amyloid deposition: A study in a transgenic mouse model of ATTRV30M amyloid neuropathy %A Panayiotou, E. %A Fella, E. %A Papacharalambous, R. %A Malas, S. %A Saraiva, M.J. %A Kyriakides, T. %B PLoS ONE %V 12 %8 2017 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017528439&doi=10.1371%2fjournal.pone.0175767&partnerID=40&md5=ef4548a6b22362064010c6c0090e5eb0 %N 4 %0 Journal Article %J Scientific Reports %D 2017 %T Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation %A Sant'Anna, R. %A Almeida, M.R. %A Varejao, N. %A Gallego, P. %A Esperante, S. %A Ferreira, P. %A Pereira-Henriques, A. %A Palhano, F.L. %A De Carvalho, M. %A Foguel, D. %A Reverter, D. %A Saraiva, M.J. %A Ventura, S. %B Scientific Reports %V 7 %8 2017 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-85016162023&doi=10.1038%2fsrep44709&partnerID=40&md5=6051bd41c380b3c50cbaccf2b26a80af %0 Journal Article %J Journal of Neuroinflammation %D 2017 %T Differential expression of Cathepsin E in transthyretin amyloidosis: From neuropathology to the immune system %A Gonçalves, N.P. %A Moreira, J. %A Martins, D. %A Vieira, P. %A Obici, L. %A Merlini, G. %A Saraiva, M. %A Saraiva, M.J. %B Journal of Neuroinflammation %V 14 %8 2017 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020206626&doi=10.1186%2fs12974-017-0891-9&partnerID=40&md5=b9f1e2ecd68f694c037715a33142d46c %N 1 %0 Journal Article %J Amyloid %D 2017 %T Doxycycline-tauroursodeoxycholic acid treatment: effects in the heart of a transthyretin V30M transgenic mouse model %A Teixeira, C. %A Costelha, S. %A Martins, H.S. %A Teixeira, A. %A Saraiva, M.J. %B Amyloid %V 24 %P 80 %8 2017 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018742465&doi=10.1080%2f13506129.2016.1277695&partnerID=40&md5=97d634128a0d04c6e498c4f3b9b04b9b %0 Journal Article %J Amyloid %D 2017 %T Efficiency of siRNA for removal of transthyretin V30M in a TTR leptomeningeal animal model %A Gonçalves, P. %A Martins, H. %A Costelha, S. %A Saraiva, M.J. %B Amyloid %V 24 %P 38 - 39 %8 2017 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018761744&doi=10.1080%2f13506129.2016.1272452&partnerID=40&md5=e849f225289203721c73e62855d9016a %0 Journal Article %J Journal of Molecular Recognition %D 2017 %T Force spectroscopy reveals the presence of structurally modified dimers in transthyretin amyloid annular oligomers %A Pires, R.H. %A Saraiva, M.J. %A Damas, A.M. %A Kellermayer, M.S.Z. %B Journal of Molecular Recognition %V 30 %8 2017 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84996636689&doi=10.1002%2fjmr.2587&partnerID=40&md5=bc8641bc3db6136a5cfa24146453ca95 %N 3 %0 Journal Article %J Amyloid %D 2017 %T The importance of pre-clinical studies in animal models of TTR amyloidosis for the discovery of novel patient disease biomarkers %A Gonçalves, N.P. %A Martins, D. %A Saraiva, M.J. %B Amyloid %V 24 %P 83 - 84 %8 2017 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018728032&doi=10.1080%2f13506129.2016.1278362&partnerID=40&md5=aa06f1bd45c30dc033d5acfe0635ebb0 %0 Journal Article %J DMM Disease Models and Mechanisms %D 2017 %T MMP-14 overexpression correlates with the neurodegenerative process in familial amyloidotic polyneuropathy %A Martins, D. %A Moreira, J. %A Gonçalves, N.P. %A Saraiva, M.J. %B DMM Disease Models and Mechanisms %V 10 %P 1253 - 1260 %8 2017 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031771832&doi=10.1242%2fdmm.028571&partnerID=40&md5=c295488f72e15dd1887eb15a7e701f7f %N 10 %0 Journal Article %J Nanomedicine %D 2017 %T Multimodal imaging Gd-nanoparticles functionalized with Pittsburgh compound B or a nanobody for amyloid plaques targeting %A Pansieri, J. %A Plissonneau, M. %A Stransky-Heilkron, N. %A Dumoulin, M. %A Heinrich-Balard, L. %A Rivory, P. %A Morfin, J.-F. %A Toth, E. %A Saraiva, M.J. %A Allémann, E. %A Tillement, O. %A Forge, V. %A Lux, F. %A Marquette, C. %B Nanomedicine %V 12 %P 1675 - 1687 %8 2017 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-85022183682&doi=10.2217%2fnnm-2017-0079&partnerID=40&md5=e04f17adc10cde37e62ddc4e46694295 %N 14 %0 Journal Article %J Scientific Reports %D 2016 %T Curcumin: A multi-Target disease-modifying agent for late-stage transthyretin amyloidosis %A Ferreira, N. %A Gonçalves, N.P. %A Saraiva, M.J. %A Almeida, M.R. %B Scientific Reports %V 6 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84969921377&doi=10.1038%2fsrep26623&partnerID=40&md5=6dba1ba0bad80de99de6426044ae291c %0 Journal Article %J Amyloid %D 2016 %T Efficiency of silencing RNA for removal of transthyretin V30M in a TTR leptomeningeal animal model %A Gonçalves, P. %A Martins, H. %A Costelha, S. %A Maia, L.F. %A Saraiva, M.J. %B Amyloid %V 23 %P 249 - 253 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84997124349&doi=10.1080%2f13506129.2016.1256282&partnerID=40&md5=7df3b3801dd8932604a8fb247164b88f %N 4 %0 Journal Article %J Biochimica et Biophysica Acta - Molecular Basis of Disease %D 2016 %T Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor %A Vieira, M. %A Leal, S.S. %A Gomes, C.M. %A Saraiva, M.J. %B Biochimica et Biophysica Acta - Molecular Basis of Disease %V 1862 %P 797 - 804 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84958526939&doi=10.1016%2fj.bbadis.2016.01.008&partnerID=40&md5=3df5d80ce654ff4b62c7eed851281863 %N 4 %0 Journal Article %J Journal of Nanobiotechnology %D 2016 %T Gd-nanoparticles functionalization with specific peptides for ß-amyloid plaques targeting %A Plissonneau, M. %A Pansieri, J. %A Heinrich-Balard, L. %A Morfin, J.-F. %A Stransky-Heilkron, N. %A Rivory, P. %A Mowat, P. %A Dumoulin, M. %A Cohen, R. %A Allémann %A Tóth %A Saraiva, M.J. %A Louis, C. %A Tillement, O. %A Forge, V. %A Lux, F. %A Marquette, C. %B Journal of Nanobiotechnology %V 14 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979272576&doi=10.1186%2fs12951-016-0212-y&partnerID=40&md5=6209a3372944548f54c22dfb5abcec38 %N 1 %0 Journal Article %J Clinical Science %D 2016 %T Impairment of autophagy by TTR V30M aggregates: In vivo reversal by TUDCA and curcumin %A Teixeira, C.A. %A Almeida, M.D.R. %A Saraiva, M.J. %B Clinical Science %V 130 %P 1665 - 1675 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014362637&doi=10.1042%2fCS20160075&partnerID=40&md5=305826da43fc67637fa64b8557d52df2 %N 18 %0 Journal Article %J European Journal of Medicinal Chemistry %D 2016 %T A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition %A Simões, C.J.V. %A Almeida, Z.L. %A Costa, D. %A Jesus, C.S.H. %A Cardoso, A.L. %A Almeida, M.R. %A Saraiva, M.J. %A Pinho e Melo, T.M.V.D. %A Brito, R.M.M. %B European Journal of Medicinal Chemistry %V 121 %P 823 - 840 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961839171&doi=10.1016%2fj.ejmech.2016.02.074&partnerID=40&md5=0f10f2da86425912e522ce94860d41a3 %0 Journal Article %J American Journal of Pathology %D 2016 %T Overexpression of Protocadherin-10 in Transthyretin-Related Familial Amyloidotic Polyneuropathy %A Gonçalves, N.P. %A Martins, D. %A Saraiva, M.J. %B American Journal of Pathology %V 186 %P 1913 - 1924 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84997207695&doi=10.1016%2fj.ajpath.2016.02.020&partnerID=40&md5=97a50338db1d0b22348de0cb62438d42 %N 7 %0 Journal Article %J Amyloid %D 2016 %T Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis %A Butler, J.S. %A Chan, A. %A Costelha, S. %A Fishman, S. %A Willoughby, J.L.S. %A Borland, T.D. %A Milstein, S. %A Foster, D.J. %A Gonçalves, P. %A Chen, Q. %A Qin, J. %A Bettencourt, B.R. %A Sah, D.W. %A Alvarez, R. %A Rajeev, K.G. %A Manoharan, M. %A Fitzgerald, K. %A Meyers, R.E. %A Nochur, S.V. %A Saraiva, M.J. %A Zimmermann, T.S. %B Amyloid %V 23 %P 109 - 118 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84962124696&doi=10.3109%2f13506129.2016.1160882&partnerID=40&md5=1d93178940883bb9f370cad870844c7f %N 2 %0 Journal Article %J Neurobiology of Aging %D 2016 %T Tissue remodeling after interference RNA mediated knockdown of transthyretin in a familial amyloidotic polyneuropathy mouse model %A Gonçalves, N.P. %A Gonçalves, P. %A Magalhaes, J. %A Ventosa, M. %A Coelho, A.V. %A Saraiva, M.J. %B Neurobiology of Aging %V 47 %P 91 - 101 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983775600&doi=10.1016%2fj.neurobiolaging.2016.07.020&partnerID=40&md5=337cf6f5cf1e218eb03882752a85af98 %0 Journal Article %J Scientific Reports %D 2016 %T Transthyretin participates in beta-amyloid transport from the brain to the liver- involvement of the low-density lipoprotein receptor-related protein 1? %A Alemi, M. %A Gaiteiro, C. %A Ribeiro, C.A. %A Santos, L.M. %A Gomes, J.R. %A Oliveira, S.M. %A Couraud, P.-O. %A Weksler, B. %A Romero, I. %A Saraiva, M.J. %A Cardoso, I. %B Scientific Reports %V 6 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957818760&doi=10.1038%2fsrep20164&partnerID=40&md5=e1accbb7f4fb11c91f9e69d98092533f %0 Journal Article %J Cell Death and Differentiation %D 2016 %T Transthyretin provides trophic support via megalin by promoting neurite outgrowth and neuroprotection in cerebral ischemia %A Gomes, J.R. %A Nogueira, R.S. %A Vieira, M. %A Santos, S.D. %A Ferraz-Nogueira, J.P. %A Relvas, J.B. %A Saraiva, M.J. %B Cell Death and Differentiation %V 23 %P 1749 - 1764 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84982105742&doi=10.1038%2fcdd.2016.64&partnerID=40&md5=a23e97a5e41a8f9206f5040924716170 %N 11 %0 Journal Article %J Journal of Controlled Release %D 2015 %T Polymer-doxycycline conjugates as fibril disrupters: An approach towards the treatment of a rare amyloidotic disease %A Conejos-Sánchez, I. %A Cardoso, I. %A Oteo-Vives, M. %A Romero-Sanz, E. %A Paul, A. %A Sauri, A.R. %A Morcillo, M.A. %A Saraiva, M.J. %A Vicent, M.J. %B Journal of Controlled Release %V 198 %P 80 - 90 %8 2015 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84917690965&partnerID=40&md5=7ebabff2949d8d53f0872031375cc88e %0 Journal Article %J Journal of Neuropathology and Experimental Neurology %D 2015 %T Protective role of anakinra against transthyretin-mediated axonal loss and cell death in a mouse model of familial amyloidotic polyneuropathy %A Gonçalves, N. P. %A Teixeira-Coelho, M. %A Saraiva, M.J. %B Journal of Neuropathology and Experimental Neurology %V 74 %P 203 - 217 %8 2015 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84923701097&partnerID=40&md5=74ea39bf45cc4d7c36e971620cf78f60 %N 3 %0 Journal Article %J Molecular Neurobiology %D 2015 %T Transthyretin Induces Insulin-like Growth Factor I Nuclear Translocation Regulating Its Levels in the Hippocampus %A Vieira, M. %A Gomes, J.R. %A Saraiva, M.J. %B Molecular Neurobiology %V 51 %P 1468 - 1479 %8 2015 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84939882016&partnerID=40&md5=83106ce98e1f4973ff7a2f7bfd5b53f1 %N 3 %0 Journal Article %J Experimental Neurology %D 2014 %T The inflammatory response to sciatic nerve injury in a familial amyloidotic polyneuropathy mouse model %A Gonçalves, N. P. %A Teixeira-Coelho, M. %A Saraiva, M.J. %B Experimental Neurology %V 257 %P 76 - 87 %8 2014 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84900864199&partnerID=40&md5=163524f36fa4204685436ca13f1efc30 %0 Journal Article %J Journal of Controlled Release %D 2014 %T Targeting a rare amyloidotic disease through rationally designed polymer conjugates %A Conejos-Sánchez, I. %A Cardoso, I. %A Saraiva, M.J. %A Vicent, M.J. %B Journal of Controlled Release %V 178 %P 95 - 100 %8 2014 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84894189251&partnerID=40&md5=f9d695bbe598cdc3ea546e78ecb6f0c9 %N 1 %0 Journal Article %J Biomolecular Concepts %D 2014 %T Transthyretin: A multifaceted protein %A Vieira, M. %A Saraiva, M.J. %B Biomolecular Concepts %V 5 %P 45 - 54 %8 2014 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84896800827&partnerID=40&md5=427aedb3d73fa6dc4656323e2834d357 %N 1 %0 Journal Article %J Journal of Alzheimer's Disease %D 2014 %T Transthyretin stabilization by iododiflunisal promotes amyloid-β peptide clearance, decreases its deposition, and ameliorates cognitive deficits in an Alzheimer's disease mouse model %A Ribeiro, C.A. %A Oliveira, S.M. %A Guido, L.F. %A Magalhães, A. %A Valencia, G. %A Arsequell, G. %A Saraiva, M.J. %A Cardoso, I. %B Journal of Alzheimer's Disease %V 39 %P 357 - 370 %8 2014 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84893904524&partnerID=40&md5=e931977e9174c4794866a1b12add2e16 %N 2 %0 Journal Article %J Biochimica et Biophysica Acta - Molecular Basis of Disease %D 2013 %T Dietary curcumin counteracts extracellular transthyretin deposition: Insights on the mechanism of amyloid inhibition %A Ferreira, N. %A Santos, S. A. O. %A Domingues, M. R. M. %A Saraiva, M.J. %A Almeida, M.R. %B Biochimica et Biophysica Acta - Molecular Basis of Disease %V 1832 %P 39 - 45 %8 2013/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84868592337&partnerID=40&md5=647a1c6ab2e5ab9f8d22abea13273854 %N 1 %0 Journal Article %J Laboratory Investigation %D 2013 %T Fibroblasts endocytose and degrade transthyretin aggregates in transthyretin-related amyloidosis %A Misumi, Y. %A Ando, Y. %A Gonçalves, N. P. %A Saraiva, M.J. %B Laboratory Investigation %V 93 %P 911 - 920 %8 2013 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84881050634&partnerID=40&md5=fa16151f89e7b247ec11923a64207c4f %N 8 %0 Journal Article %J Biochimica et Biophysica Acta - Molecular Basis of Disease %D 2013 %T Hepatic production of transthyretin L12P leads to intracellular lysosomal aggregates in a new somatic transgenic mouse model %A Batista, A.R. %A Sena-Esteves, M. %A Saraiva, M.J. %B Biochimica et Biophysica Acta - Molecular Basis of Disease %V 1832 %P 1183 - 1193 %8 2013 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84877340049&partnerID=40&md5=4e2ecb6698f94eb53a8bfd3d8eb44e1b %N 8 %0 Journal Article %J Amyloid %D 2013 %T Hsf-1 affects podocyte markers NPHS1, NPHS2 and WT1 in a transgenic mouse model of TTRVal30Met-related amyloidosis %A Petrakis, I. %A Mavroeidi, V. %A Stylianou, K. %A Andronikidi, E. %A Lioudaki, E. %A Perakis, K. %A Stratigis, S. %A Vardaki, E. %A Zafeiri, M. %A Giannakakis, K. %A Plaitakis, A. %A Amoiridis, G. %A Saraiva, M.J. %A Daphnis, E. %B Amyloid %V 20 %P 164 - 172 %8 2013 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84882933912&partnerID=40&md5=5bd0c87e60d14d6b724e3a710a224917 %N 3 %0 Journal Article %J Transgenic Research %D 2013 %T Human TTRV30M localization within podocytes in a transgenic mouse model of transthyretin related amyloidosis: Does the environment play a role? %A Petrakis, I. %A Mavroeidi, V. %A Stylianou, K. %A Efthymiou, G. %A Perakis, K. %A Vardaki, E. %A Stratigis, S. %A Giannakakis, K. %A Kourouniotis, K. %A Amoiridis, G. %A Plaitakis, A. %A Saraiva, M.J. %A Yamamura, K. I. %A Daphnis, E. %B Transgenic Research %V 22 %P 101 - 116 %8 2013/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84871390163&partnerID=40&md5=e7682292738ae9b5287613971ebf9479 %N 1 %0 Journal Article %J Journal of Cellular and Molecular Medicine %D 2013 %T Presence of N-glycosylated transthyretin in plasma of V30M carriers in familial amyloidotic polyneuropathy: An escape from ERAD %A Teixeira, A.C. %A Saraiva, M.J. %B Journal of Cellular and Molecular Medicine %V 17 %P 429 - 435 %8 2013 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84875784710&partnerID=40&md5=06dd8c1d35d4b3d94e773a4b8e7b73da %N 3 %0 Journal Article %J FEBS Letters %D 2013 %T Transthyretin regulates hippocampal 14-3-3ζ protein levels %A Vieira, M. %A Saraiva, M.J. %B FEBS Letters %V 587 %P 1482 - 1488 %8 2013 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84877742326&partnerID=40&md5=89be84c52155c1d708a7c1e38efe7a75 %N 10 %0 Journal Article %J FEBS Letters %D 2012 %T Clearance of extracellular misfolded proteins in systemic amyloidosis: Experience with transthyretin %A Almeida, M.R. %A Saraiva, M.J. %B FEBS Letters %V 586 %P 2891 - 2896 %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84864931018&partnerID=40&md5=7e26ae250f6b885e94435e7a9b447aae %N 18 %0 Journal Article %J PLoS ONE %D 2012 %T Distinct Annular Oligomers Captured along the Assembly and Disassembly Pathways of Transthyretin Amyloid Protofibrils %A Pires, R.H. %A Karsai, Á. %A Saraiva, M.J. %A Damas, A.M. %A Kellermayer, M.S.Z. %B PLoS ONE %V 7 %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84866318129&partnerID=40&md5=87126afbfde459837bcd031cf40d5a5d %N 9 %0 Journal Article %J Amyloid %D 2012 %T Doxycycline plus tauroursodeoxycholic acid for transthyretin amyloidosis: A phase II study %A Obici, L. %A Cortese, A. %A Lozza, A. %A Lucchetti, J. %A Gobbi, M. %A Palladini, G. %A Perlini, S. %A Saraiva, M.J. %A Merlini, G. %B Amyloid %V 19 %P 34 - 36 %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84861423778&partnerID=40&md5=a37fc893196a50627b0e0c02f8808946 %N SUPPL. 1 %0 Journal Article %J PLoS ONE %D 2012 %T Epigallocatechin-3-gallate as a potential therapeutic drug for TTR-related amyloidosis: "In vivo" evidence from FAP mice models %A Ferreira, N. %A Saraiva, M.J. %A Almeida, M.R. %B PLoS ONE %V 7 %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84855650426&partnerID=40&md5=3a4219629a4b3d658732a82d3448a7e4 %N 1 %0 Journal Article %J Amyloid %D 2012 %T The heat shock response in FAP: The role of the extracellular chaperone clusterin %A Magalhães, J. %A Saraiva, M.J. %B Amyloid %V 19 %P 3 - 4 %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84861451360&partnerID=40&md5=cd710861696847e22e80aa111adaec70 %N SUPPL. 1 %0 Journal Article %J Amyloid %D 2012 %T Natural polyphenols as modulators of TTR amyloidogenesis: In vitro and in vivo evidences towards therapy %A Ferreira, N. %A Saraiva, M.J. %A Almeida, M.R. %B Amyloid %V 19 %P 39 - 42 %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84861433687&partnerID=40&md5=850a84457e12b3b1a1ebabc339a6f5c8 %N SUPPL. 1 %0 Journal Article %J Nanomedicine %D 2012 %T A novel nanoparticle delivery system for in vivo targeting of the sciatic nerve: Impact on regeneration %A Gonçalves, N. P. %A Oliveira, H. %A Pêgo, A.P. %A Saraiva, M.J. %B Nanomedicine %V 7 %P 1167 - 1180 %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84868111412&partnerID=40&md5=5db0c76b3a921ca70565c9f3f63cf004 %N 8 %0 Journal Article %J PLoS ONE %D 2012 %T Stability of the Transthyretin Molecule as a Key Factor in the Interaction with A-Beta Peptide - Relevance in Alzheimer's Disease %A Ribeiro, C.A. %A Saraiva, M.J. %A Cardoso, I. %B PLoS ONE %V 7 %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84866460552&partnerID=40&md5=a0dfc2da5c8192925b47d6c264949fff %N 9 %0 Journal Article %J Current Alzheimer Research %D 2012 %T Transthyretin decrease in plasma of MCI and AD patients: Investigation of mechanisms for disease modulation %A Ribeiro, C.A. %A Santana, I. %A Oliveira, C. %A Baldeiras, I. %A Moreira, J. %A Saraiva, M.J. %A Cardoso, I. %B Current Alzheimer Research %V 9 %P 881 - 889 %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84867714724&partnerID=40&md5=3b8da808aabf04d44b80fdeced72c93b %N 8 %0 Journal Article %J Current Medicinal Chemistry %D 2012 %T Transthyretin deposition in familial amyloidotic polyneuropathy %A Saraiva, M.J. %A Magalhaes, J. %A Ferreira, N. %A Almeida, M.R. %B Current Medicinal Chemistry %V 19 %P 2304 - 2311 %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84860663436&partnerID=40&md5=962004f2e8e201193cd9a0e0f5657bee %N 15 %0 Journal Article %J Biochemical Journal %D 2012 %T Transthyretin is a metallopeptidase with an inducible active site %A Liz, M.A. %A Leite, S. C. %A Juliano, L. %A Saraiva, M.J. %A Damas, A.M. %A Bur, D. %A Sousa, M.M. %B Biochemical Journal %V 443 %P 769 - 778 %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84860178075&partnerID=40&md5=a10f2d32c644636fc246d7f79a171d2c %N 3 %0 Journal Article %J Journal of Neuropathology and Experimental Neurology %D 2011 %T Clusterin overexpression and its possible protective role in transthyretin deposition in familial amyloidotic polyneuropathy %A Magalhães, J. %A Saraiva, M.J. %B Journal of Neuropathology and Experimental Neurology %V 70 %P 1097 - 1106 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-81855199979&partnerID=40&md5=d083876d17665957abe15c74b03ee754 %N 12 %0 Journal Article %J Journal of Alzheimer's Disease %D 2011 %T Gender-dependent transthyretin modulation of brain amyloid-β Levels: Evidence from a mouse model of alzheimer's disease %A Oliveira, S.M. %A Ribeiro, C.A. %A Cardoso, I. %A Saraiva, M.J. %B Journal of Alzheimer's Disease %V 27 %P 429 - 439 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-81855226408&partnerID=40&md5=366b9b479b431768dd24a7c10f0cccd5 %N 2 %0 Journal Article %J Proceedings of the National Academy of Sciences of the United States of America %D 2011 %T Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein %A Noborna, F. %A O'Callaghan, P. %A Hermansson, E. %A Zhang, X. %A Ancsin, J.B. %A Damas, A.M. %A Dacklin, I. %A Presto, J. %A Johansson, J. %A Saraiva, M.J. %A Lundgren, E. %A Kisilevsky, R. %A Westermark, P. %A Li, J.-P. %B Proceedings of the National Academy of Sciences of the United States of America %V 108 %P 5584 - 5589 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-79954990699&partnerID=40&md5=0a45c032e50290ca13d37fae9cbb2d1d %N 14 %0 Journal Article %J FEBS Letters %D 2011 %T Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation %A Ferreira, N. %A Saraiva, M.J. %A Almeida, M.R. %B FEBS Letters %V 585 %P 2424 - 2430 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-79960910835&partnerID=40&md5=280da17ba91b02d23308cfcba9f21a31 %N 15 %0 Journal Article %J Journal of Molecular Neuroscience %D 2011 %T Progesterone enhances transthyretin expression in the rat choroid plexus in vitro and in vivo via progesterone receptor %A Quintela, T. %A Gonçalves, I. %A Martinho, A. %A Alves, C.H. %A Saraiva, M.J. %A Rocha, P. %A Santos, C.R.A. %B Journal of Molecular Neuroscience %V 44 %P 152 - 158 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-80054082420&partnerID=40&md5=500e49fa5b69ae4c0cc22cd99f4c297e %N 3 %0 Journal Article %J Journal of Biological Chemistry %D 2011 %T Solution structure of the soluble receptor for advanced glycation end products (sRAGE) %A Sárkány, Z. %A Ikonen, T.P. %A Ferreira-Da-Silva, F. %A Saraiva, M.J. %A Svergun, D. %A Damas, A.M. %B Journal of Biological Chemistry %V 286 %P 37525 - 37534 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-80054814015&partnerID=40&md5=1e182fd947c34ba004f9841b73e692af %N 43 %0 Journal Article %J Acta Crystallographica Section D: Biological Crystallography %D 2011 %T Structural insights into a zinc-dependent pathway leading to Leu55Pro transthyretin amyloid fibrils %A Castro-Rodrigues, A.F. %A Gales, L. %A Saraiva, M.J. %A Damas, A.M. %B Acta Crystallographica Section D: Biological Crystallography %V 67 %P 1035 - 1044 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-82455198838&partnerID=40&md5=0645f8740abbb950ca2171a6957fe25e %N 12 %0 Journal Article %J Journal of Molecular Recognition %D 2011 %T Structure and assembly-disassembly properties of wild-type transthyretin amyloid protofibrils observed with atomic force microscopy %A Pires, R.H. %A Saraiva, M.J. %A Damas, A.M. %A Kellermayer, M.S.Z. %B Journal of Molecular Recognition %V 24 %P 467 - 476 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-79955124353&partnerID=40&md5=bc22f8a916d50ac2488a0a032fe1cf64 %N 3 %0 Journal Article %J Transplantation %D 2011 %T Successful heart and liver transplantation in a swiss patient with glu89lys transthyretin amyloidosis %A Niederhauser, J. %A Lobrinus, J.A. %A Ochsner, F. %A Wider, C. %A Fellmann, F. %A Yerly, P. %A Antonino, A.T. %A Saraiva, M.J. %A Moradpour, D. %A Kuntzer, T. %B Transplantation %V 91 %P e40 - e42 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-79952756738&partnerID=40&md5=cf899d4a6598ef5855d04b0c41a055a7 %N 6 %0 Journal Article %J Pharmacological Research %D 2010 %T Carvedilol treatment reduces transthyretin deposition in a familial amyloidotic polyneuropathy mouse model %A Macedo, B. %A Magalhães, J. %A Batista, A.R. %A Saraiva, M.J. %B Pharmacological Research %V 62 %P 514 - 522 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-78049528674&partnerID=40&md5=842d6354261e0cf274c27f82c3a42eee %N 6 %0 Journal Article %J ChemBioChem %D 2010 %T Controlling amyloid-β peptide(1-42) oligomerization and toxicity by fluorinated nanoparticles %A Saraiva, A.M. %A Cardoso, I. %A Pereira, M.C. %A Coelho, M.A.N. %A Saraiva, M.J. %A Möhwald, H. %A Brezesinski, G. %B ChemBioChem %V 11 %P 1905 - 1913 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-77956253706&partnerID=40&md5=b542967bdceac2f960a6b916416c05d9 %N 13 %0 Journal Article %J Journal of Neurochemistry %D 2010 %T CSF transthyretin neuroprotection in a mouse model of brain ischemia %A Santos, S.D. %A Lambertsen, K.L. %A Clausen, B.H. %A Akinc, A. %A Alvarez, R. %A Finsen, B. %A Saraiva, M.J. %B Journal of Neurochemistry %V 115 %P 1434 - 1444 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-78650023374&partnerID=40&md5=e1f5719cb08d1a742e0859f007cfe6ac %N 6 %0 Journal Article %J Neurobiology of Aging %D 2010 %T The heat shock response modulates transthyretin deposition in the peripheral and autonomic nervous systems %A Santos, S.D. %A Fernandes, R. %A Saraiva, M.J. %B Neurobiology of Aging %V 31 %P 280 - 289 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-71349088766&partnerID=40&md5=9cbceeed9e022c7ba7525c4ff755669b %N 2 %0 Journal Article %J FEBS Journal %D 2010 %T Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin %A Martinho, A. %A Gonçalves, I. %A Cardoso, I. %A Almeida, M.R. %A Quintela, T. %A Saraiva, M.J. %A Santos, C.R.A. %B FEBS Journal %V 277 %P 3427 - 3436 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-77955239777&partnerID=40&md5=8e3d909df1ca346d05af4045651d0b7d %N 16 %0 Journal Article %J Macromolecular Bioscience %D 2010 %T Randomization of Amyloid-β-Peptide(1-42) Conformation by Sulfonated and Sulfated Nanoparticles Reduces Aggregation and Cytotoxicity %A Saraiva, A.M. %A Cardoso, I. %A Saraiva, M.J. %A Tauer, K. %A Pereira, M.C. %A Coelho, M.A.N. %A Möhwald, H. %A Brezesinski, G. %B Macromolecular Bioscience %V 10 %P 1152 - 1163 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-78349265390&partnerID=40&md5=6e14b6224f7f2107acc29f0558258880 %N 10 %0 Journal Article %J Journal of Translational Medicine %D 2010 %T Synergy of combined Doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: Studies in FAP mouse models %A Cardoso, I. %A Martins, D. %A Ribeiro, T. %A Merlini, G. %A Saraiva, M.J. %B Journal of Translational Medicine %V 8 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-77954988796&partnerID=40&md5=4e545612ae485e8573fbd602222b48be %0 Journal Article %J International Journal of Experimental Pathology %D 2010 %T αB-crystallin (HspB5) in familial amyloidotic polyneuropathy %A Magalhães, J. %A Santos, S.D. %A Saraiva, M.J. %B International Journal of Experimental Pathology %V 91 %P 515 - 521 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-78649515958&partnerID=40&md5=9d02f976955cf2ad57c4022e2d194f8a %N 6 %0 Journal Article %J Cellular and Molecular Neurobiology %D 2009 %T 17β-estradiol induces transthyretin expression in murine choroid plexus via an oestrogen receptor dependent pathway %A Quintela, T. %A Gonçalves, I. %A Baltazar, G. %A Alves, C.H. %A Saraiva, M.J. %A Santos, C.R.A. %B Cellular and Molecular Neurobiology %V 29 %P 475 - 483 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-67449156413&partnerID=40&md5=ab9fe51959e0d1e566f3cc7d5a7fb7af %N 4 %0 Journal Article %J FEBS Letters %D 2009 %T Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity %A Ferreira, N. %A Cardoso, I. %A Domingues, M.R. %A Vitorino, R. %A Bastos, M. %A Bai, G. %A Saraiva, M.J. %A Almeida, M.R. %B FEBS Letters %V 583 %P 3569 - 3576 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-71749085436&partnerID=40&md5=811ef79e7b3739a73a8a833f12c37ec5 %N 22 %0 Journal Article %J Biochemical and Biophysical Research Communications %D 2009 %T Design and biological activity of β-sheet breaker peptide conjugates %A Rocha, S. %A Cardoso, I. %A Börner, H. %A Pereira, M.C. %A Saraiva, M.J. %A Coelho, M. %B Biochemical and Biophysical Research Communications %V 380 %P 397 - 401 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-60349104142&partnerID=40&md5=85946aef98ca4dc7b0be673d7a86b8cd %N 2 %0 Journal Article %J PLoS ONE %D 2009 %T Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors. %A Mairal, T. %A Nieto, J. %A Pinto, M. %A Almeida, M.R. %A Gales, L. %A Ballesteros, A. %A Barluenga, J. %A Pérez, J.J. %A Vázquez, J.T. %A Centeno, N.B. %A Saraiva, M.J. %A Damas, A.M. %A Planas, A. %A Arsequell, G. %A Valencia, G. %B PLoS ONE %V 4 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-59249100931&partnerID=40&md5=f198d6ea26cef74066becb41f537c7cd %N 1 %0 Journal Article %J PLoS ONE %D 2009 %T Iodine atoms: A new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors %A Mairal, T. %A Nieto, J. %A Pinto, M. %A Almeida, M.R. %A Gales, L. %A Ballesteros, A. %A Barluenga, J. %A Pérez, J.J. %A Vázquez, J.T. %A Centeno, N.B. %A Saraiva, M.J. %A Damas, A.M. %A Planas, A. %A Arsequell, G. %A Valencia, G. %B PLoS ONE %V 4 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-76549107471&partnerID=40&md5=3c50b3f528228e1cdcbdf338d86ca8ca %N 1 %0 Journal Article %J Bioorganic and Medicinal Chemistry Letters %D 2009 %T Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors %A González, A. %A Quirante, J. %A Nieto, J. %A Almeida, M.R. %A Saraiva, M.J. %A Planas, A. %A Arsequell, G. %A Valencia, G. %B Bioorganic and Medicinal Chemistry Letters %V 19 %P 5270 - 5273 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-68549085257&partnerID=40&md5=b4cf7ffd46ddb61e0d802b209c39334d %N 17 %0 Journal Article %J Journal of Neuroscience %D 2009 %T Transthyretin internalization by sensory neurons is megalin mediated and necessary for its neuritogenic activity %A Fleming, C.E. %A Mar, F.M. %A Franquinho, F. %A Saraiva, M.J. %A Sousa, M.M. %B Journal of Neuroscience %V 29 %P 3220 - 3232 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-63849199799&partnerID=40&md5=83963e483535453d953104df3c18aa7f %N 10 %0 Journal Article %J Brain Research %D 2008 %T 5α-dihydrotestosterone up-regulates transthyretin levels in mice and rat choroid plexus via an androgen receptor independent pathway %A Quintela, T. %A Alves, C.H. %A Gonçalves, I. %A Baltazar, G. %A Saraiva, M.J. %A Santos, C.R.A. %B Brain Research %V 1229 %P 18 - 26 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-49849091809&partnerID=40&md5=5ef9298fe6436cc5656fc496a2e39043 %0 Journal Article %J Journal of Neuropathology and Experimental Neurology %D 2008 %T Activation of the heat shock response in familial amyloidotic polyneuropathy %A Santos, S.D. %A Magalhães, J. %A Saraiva, M.J. %B Journal of Neuropathology and Experimental Neurology %V 67 %P 449 - 455 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-43249124993&partnerID=40&md5=6b03a31f0fda714bddf1e2f71eac4878 %N 5 %0 Journal Article %J FEBS Letters %D 2008 %T Amyloidogenic properties of transthyretin-like protein (TLP) from Escherichia coli %A Santos, S.D. %A Costa, R. %A Teixeira, P.F. %A Gottesman, M. %A Cardoso, I. %A Saraiva, M.J. %B FEBS Letters %V 582 %P 2893 - 2898 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-48749127539&partnerID=40&md5=226fe223f9cd17ff866d8d30fde172aa %N 19 %0 Journal Article %J Biochimica et Biophysica Acta - Molecular Basis of Disease %D 2008 %T Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy %A Macedo, B. %A Batista, A.R. %A Ferreira, N. %A Almeida, M.R. %A Saraiva, M.J. %B Biochimica et Biophysica Acta - Molecular Basis of Disease %V 1782 %P 517 - 522 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-49349097870&partnerID=40&md5=0504bdb8449a5ce447da5feb06674ee6 %N 9 %0 Journal Article %J Disease Markers %D 2008 %T Extracellular matrix markers for disease progression and follow-up of therapies in familial amyloid polyneuropathy V30M TTR-related %A Cardoso, I. %A Brito, M. %A Saraiva, M.J. %B Disease Markers %V 25 %P 37 - 47 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-50249169221&partnerID=40&md5=81e51d4cb7675f693c1aa8a82ba14b67 %N 1 %0 Journal Article %J Biochimica et Biophysica Acta - Proteins and Proteomics %D 2008 %T Iodination of salicylic acid improves its binding to transthyretin %A Gales, L. %A Almeida, M.R. %A Arsequell, G. %A Valencia, G. %A Saraiva, M.J. %A Damas, A.M. %B Biochimica et Biophysica Acta - Proteins and Proteomics %V 1784 %P 512 - 517 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-43049162388&partnerID=40&md5=ef1bf96239ccea9c357c15a1c430e7d9 %N 3 %0 Journal Article %J FEBS Letters %D 2008 %T Transthyretin binding to A-Beta peptide - Impact on A-Beta fibrillogenesis and toxicity %A Costa, R. %A Gonçalves, A. %A Saraiva, M.J. %A Cardoso, I. %B FEBS Letters %V 582 %P 936 - 942 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-40149086952&partnerID=40&md5=b0d6992afb840ae8f064de549718a3a7 %N 6 %0 Journal Article %J Experimental Neurology %D 2008 %T Transthyretin is not expressed by dorsal root ganglia cells %A Sousa, M.M. %A Saraiva, M.J. %B Experimental Neurology %V 214 %P 362 - 365 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-56349106019&partnerID=40&md5=85691d0172fa5dd81d01158a2968961c %N 2 %0 Journal Article %J PLoS ONE %D 2008 %T Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: A mechanism sensitive to the kunitz protease inhibitor %A Costa, R. %A Ferreira-Da-Silva, F. %A Saraiva, M.J. %A Cardoso, I. %B PLoS ONE %V 3 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-51449096179&partnerID=40&md5=3e177d160640c25dd736e373e8674d7b %N 8 %0 Journal Article %J Journal of Neuroscience %D 2007 %T Accelerated Aβ deposition in APPswe/PS1ΔE9 mice with hemizygous deletions of TTR (transthyretin) %A Se, H.C. %A Leight, S.N. %A Lee, V.M.-Y. %A Li, T. %A Wong, P.C. %A Johnson, J.A. %A Saraiva, M.J. %A Sisodia, S.S. %B Journal of Neuroscience %V 27 %P 7006 - 7010 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-34347364708&partnerID=40&md5=fe6c961bd198393502e3effe5fbcedff %N 26 %0 Journal Article %J Journal of Lipid Research %D 2007 %T ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicity %A Liz, M.A. %A Gomes, C.M. %A Saraiva, M.J. %A Sousa, M.M. %B Journal of Lipid Research %V 48 %P 2385 - 2395 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-35848967214&partnerID=40&md5=1f602c3eef034920c7b5e648c0d9cb36 %N 11 %0 Journal Article %J Molecular Medicine %D 2007 %T Biomarkers in the assessment of therapies for familial amyloidotic polyneuropathy %A Macedo, B. %A Batista, A.R. %A Do Amaral, J.B. %A Saraiva, M.J. %B Molecular Medicine %V 13 %P 584 - 591 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-36849096153&partnerID=40&md5=c97d9b2e7a6637ff3cf8e866249b362a %N 11-12 %0 Journal Article %J Biochemical Journal %D 2007 %T Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: Relevance in drug design %A Cardoso, I. %A Almeida, M.R. %A Ferreira, N. %A Arsequell, G. %A Valencia, G. %A Saraiva, M.J. %B Biochemical Journal %V 408 %P 131 - 138 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-36348960658&partnerID=40&md5=a11be6d9183785b213d1ee7ad796276b %N 1 %0 Journal Article %J Electrophoresis %D 2007 %T Genetic microheterogeneity of human transthyretin detected by IEF %A Altland, K. %A Benson, M.D. %A Costello, C.E. %A Ferlini, A. %A Hazenberg, B.P.C. %A Hund, E. %A Kristen, A.V. %A Linke, R.P. %A Merlini, G. %A Salvi, F. %A Saraiva, M.J. %A Singer, R. %A Skinner, M. %A Winter, P. %B Electrophoresis %V 28 %P 2053 - 2064 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-34447271771&partnerID=40&md5=3783cb1408f7c43a1a52d1b746ae3392 %N 12 %0 Journal Article %J Journal of Pathology %D 2007 %T Impairment of the ubiquitin-proteasome system associated with extracellular transthyretin aggregates in familial amyloidotic polyneuropathy %A Santos, S.D. %A Cardoso, I. %A Magalhães, J. %A Saraiva, M.J. %B Journal of Pathology %V 213 %P 200 - 209 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-35348937731&partnerID=40&md5=482f98b830ce45b3f8b85a4e22658985 %N 2 %0 Journal Article %J Amyloid %D 2007 %T A primer of amyloid nomenclature %A Westermark, P. %A Benson, M.D. %A Buxbaum, J.N. %A Cohen, A.S. %A Frangione, B. %A Ikeda, S.-I. %A Masters, C.L. %A Merlini, G. %A Saraiva, M.J. %A Sipe, J.D. %B Amyloid %V 14 %P 179 - 183 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-34547913439&partnerID=40&md5=8c948b61d2a53517054e2a820457338e %N 3 %0 Journal Article %J Biochimica et Biophysica Acta - Proteins and Proteomics %D 2007 %T Structural basis for the protective role of sulfite against transthyretin amyloid formation %A Gales, L. %A Saraiva, M.J. %A Damas, A.M. %B Biochimica et Biophysica Acta - Proteins and Proteomics %V 1774 %P 59 - 64 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33846117955&partnerID=40&md5=17fca5b67bb79c6b143645e3a7a127db %N 1 %0 Journal Article %J Neurobiology of Aging %D 2007 %T Transthyretin and Alzheimer's disease: Where in the brain? %A Sousa, J.C. %A Cardoso, I. %A Marques, F. %A Saraiva, M.J. %A Palha, J.A. %B Neurobiology of Aging %V 28 %P 713 - 718 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33847345982&partnerID=40&md5=25b127ef65fc87b0b083cafb1e7abf78 %N 5 %0 Journal Article %J Journal of Neurochemistry %D 2007 %T Transthyretin enhances nerve regeneration %A Fleming, C.E. %A Saraiva, M.J. %A Sousa, M.M. %B Journal of Neurochemistry %V 103 %P 831 - 839 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-34848818080&partnerID=40&md5=35aebeab8665985741e3fa5c178045b4 %N 2 %0 Journal Article %J Journal of Psychiatric Research %D 2007 %T Transthyretin: No association between serum levels or gene variants and schizophrenia %A Ruano, D. %A Macedo, A. %A Soares, M.J. %A Valente, J. %A Azevedo, M.H. %A Hutz, M.H. %A Gama, C.S. %A Lobato, M.I. %A Belmonte-de-Abreu, P. %A Goodman, A.B. %A Pato, C. %A Saraiva, M.J. %A Heutink, P. %A Palha, J.A. %B Journal of Psychiatric Research %V 41 %P 667 - 672 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33947663895&partnerID=40&md5=9856da904a660f965a6e0bbb048a6d74 %N 8 %0 Journal Article %J Journal of Neurochemistry %D 2006 %T Activation of ERK1/2 MAP kinases in familial amyloidotic polyneuropathy %A Monteiro, F.A. %A Sousa, M.M. %A Cardoso, I. %A Do Amaral, J.B. %A Guimarães, A. %A Saraiva, M.J. %B Journal of Neurochemistry %V 97 %P 151 - 161 %8 2006/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33644951055&partnerID=40&md5=a80dca988de81f6c4ce57f2b0b9cec7d %N 1 %0 Journal Article %J Acta Crystallographica Section D: Biological Crystallography %D 2006 %T The binding of 2,4-dinitrophenol to wild-type and amyloidogenic transthyretin %A Morais-De-Sá, E. %A Neto-Silva, R.M. %A Pereira, P.J.B. %A Saraiva, M.J. %A Damas, A.M. %B Acta Crystallographica Section D: Biological Crystallography %V 62 %P 512 - 519 %8 2006/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33646538797&partnerID=40&md5=338596bd3e63c2c24bf943c16da8c833 %N 5 %0 Journal Article %J FASEB Journal %D 2006 %T Doxycycline disrupts transthyretin amyloid: Evidence from studies in a FAP transgenic mice model %A Cardoso, I. %A Saraiva, M.J. %B FASEB Journal %V 20 %P 234 - 239 %8 2006/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33644919388&partnerID=40&md5=95aeaf885f334f0968f8be8124190c1f %N 2 %0 Journal Article %J Journal of Biological Chemistry %D 2006 %T Endoplasmic reticulum stress associated with extracellular aggregates: Evidence from transthyretin deposition in familial amyloid polyneuropathy %A Teixeira, P.F. %A Cerca, F. %A Santos, S.D. %A Saraiva, M.J. %B Journal of Biological Chemistry %V 281 %P 21998 - 22003 %8 2006/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33746814859&partnerID=40&md5=1527690776df3238c8ef0c9af77029a3 %N 31 %0 Journal Article %J Laboratory Investigation %D 2006 %T Immunization in familial amyloidotic polyneuropathy: Counteracting deposition by immunization with a Y78F TTR mutant %A Terazaki, H. %A Ando, Y. %A Fernandes, R. %A Yamamura, K.-I. %A Maeda, S. %A Saraiva, M.J. %B Laboratory Investigation %V 86 %P 23 - 31 %8 2006/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-32844473029&partnerID=40&md5=59870e65ae8c707030fc2fabbbb1ad2a %N 1 %0 Journal Article %J FEBS Letters %D 2006 %T In vitro inhibition of transthyretin aggregate-induced cytotoxicity by full and peptide derived forms of the soluble receptor for advanced glycation end products (RAGE) %A Monteiro, F.A. %A Cardoso, I. %A Sousa, M.M. %A Saraiva, M.J. %B FEBS Letters %V 580 %P 3451 - 3456 %8 2006/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33646925693&partnerID=40&md5=2846be0696b1b600db21d05b697a5047 %N 14 %0 Journal Article %J FASEB Journal %D 2006 %T Transthyretin knockouts are a new mouse model for increased neuropeptide Y %A Nunes, A.F. %A Saraiva, M.J. %A Sousa, M.M. %B FASEB Journal %V 20 %P 166 - 168 %8 2006/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-30744463914&partnerID=40&md5=e0c56af329be5a5556f91a1d4065f2a0 %N 1 %0 Journal Article %J Amyloid %D 2005 %T Amyloid: Toward terminology clarification: Report from the Nomenclature Committee of the International Society Of Amyloidosis %A Westermark, P. %A Benson, M.D. %A Buxbaum, J.N. %A Cohen, A.S. %A Frangione, B. %A Ikeda, S.-I. %A Masters, C.L. %A Merlini, G. %A Saraiva, M.J. %A Sipe, J.D. %B Amyloid %V 12 %P 1 - 4 %8 2005/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-21244471488&partnerID=40&md5=e85f0145e3c5c04c572c9472e754ef48 %N 1 %0 Journal Article %J Biochemical Pharmacology %D 2005 %T The binding of xanthone derivatives to transthyretin %A Maia, F. %A Almeida, M.D.R. %A Gales, L. %A Kijjoa, A. %A Pinto, M.M.M. %A Saraiva, M.J. %A Damas, A.M. %B Biochemical Pharmacology %V 70 %P 1861 - 1869 %8 2005/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-27744528447&partnerID=40&md5=7c93acb645a047686e7d0f1ce0f0b9d2 %N 12 %0 Journal Article %J Biochemical Journal %D 2005 %T Human transthyretin in complex with iododiflunisal: Structural features associated with a potent amyloid inhibitor %A Gales, L. %A Macedo-Ribeiro, S. %A Arsequell, G. %A Valencia, G. %A Saraiva, M.J. %A Damas, A.M. %B Biochemical Journal %V 388 %P 615 - 621 %8 2005/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-20544432502&partnerID=40&md5=fb1f280ed65d3acbafe190a6c6616e93 %N 2 %0 Journal Article %J Current Drug Targets: CNS and Neurological Disorders %D 2005 %T Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses %A Almeida, M.R. %A Gales, L. %A Damas, A.M. %A Cardoso, I. %A Saraiva, M.J. %B Current Drug Targets: CNS and Neurological Disorders %V 4 %P 587 - 596 %8 2005/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-26844484754&partnerID=40&md5=af4ca78d8342a69428684780d78b9e87 %N 5 %0 Journal Article %J Human Molecular Genetics %D 2005 %T Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: Complexity in a single-gene disease %A Soares, M.L. %A Coelho, T. %A Sousa, A. %A Batalov, S. %A Conceição, I. %A Sales-Luís, M.L. %A Ritchie, M.D. %A Williams, S.M. %A Nievergelt, C.M. %A Schork, N.J. %A Saraiva, M.J. %A Buxbaum, J.N. %B Human Molecular Genetics %V 14 %P 543 - 553 %8 2005/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-14044275133&partnerID=40&md5=5f500d0e193d96fb0a5345b92d71b2ba %N 4 %0 Journal Article %J Journal of Endocrinology %D 2005 %T Transthyretin is not necessary for thyroid hormone metabolism in conditions of increased hormone demand %A Sousa, J.C. %A Morreale de Escobar, G. %A Oliveira, P. %A Saraiva, M.J. %A Palha, J.A. %B Journal of Endocrinology %V 187 %P 257 - 266 %8 2005/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-28044432318&partnerID=40&md5=43094d768ab19396e88f3beb3fa4ac3e %N 2 %0 Journal Article %J FASEB Journal %D 2005 %T Up-regulation of the extracellular matrix remodeling genes, biglycan, neutrophil gelatinase-associated lipocalin, and matrix metalloproteinase-9 in familial amyloid polyneuropathy %A Sousa, M.M. %A Do Amaral, J.B. %A Guimarães, A. %A Saraiva, M.J. %B FASEB Journal %V 19 %P 124 - 126 %8 2005/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-11244280869&partnerID=40&md5=c12a25ef29d75356ace32fde2a907338 %N 1 %0 Journal Article %J Acta Crystallographica Section D: Biological Crystallography %D 2005 %T X-ray crystallographic studies of two transthyretin variants: Further insights into amyloidogenesis %A Neto-Silva, R.M. %A Macedo-Ribeiro, S. %A Pereira, P.J.B. %A Coll, M. %A Saraiva, M.J. %A Damas, A.M. %B Acta Crystallographica Section D: Biological Crystallography %V 61 %P 333 - 339 %8 2005/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-24044453447&partnerID=40&md5=17b3c85c5e78599513794d167c43a49e %N 3 %0 Journal Article %J Journal of medical genetics %D 2004 %T Common origin of the Val30Met mutation responsible for the amyloidogenic transthyretin type of familial amyloidotic polyneuropathy. %A Ohmori, H. %A Ando, Y. %A Makita, Y. %A Onouchi, Y. %A Nakajima, T. %A Saraiva, M.J. %A Terazaki, H. %A Suhr, O. %A Sobue, G. %A Nakamura, M. %A Yamaizumi, M. %A Munar-Ques, M. %A Inoue, I. %A Uchino, M. %A Hata, A. %B Journal of medical genetics %V 41 %8 2004/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-2342614233&partnerID=40&md5=fb2e8747448af9b1e28fcf2650bb3b32 %N 4 %0 Journal Article %J Journal of Biological Chemistry %D 2004 %T The crystal structure of transthyretin in complex with diethylstilbestrol: A promising template for the design of amyloid inhibitors %A Morais-De-Sá, E. %A Pereira, P.J.B. %A Saraiva, M.J. %A Damas, A.M. %B Journal of Biological Chemistry %V 279 %P 53483 - 53490 %8 2004/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-11144228259&partnerID=40&md5=9bc279cfac2c622c206f52ea849fc5ef %N 51 %0 Journal Article %J Laboratory Investigation %D 2004 %T Deposition and passage of transthyretin through blood-nerve barrier in recipients of familial amyloid polyneuropathy livers %A Sousa, M.M. %A Ferraõ, J. %A Fernandes, R. %A Guimarães, A. %A Geraldes, J.B. %A Perdigoto, R. %A Tomé, L. %A Mota, O. %A Negrão, L. %A Furtado, A.L. %A Saraiva, M.J. %B Laboratory Investigation %V 84 %P 865 - 873 %8 2004/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-3042693562&partnerID=40&md5=5d9af28318ad98afbc1eed51de408516 %N 7 %0 Journal Article %J Neuroscience %D 2004 %T Enlarged ventricles, astrogliosis and neurodegeneration in heat shock factor 1 null mouse brain %A Santos, S.D. %A Saraiva, M.J. %B Neuroscience %V 126 %P 657 - 663 %8 2004/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-2942525558&partnerID=40&md5=153acbb0dce37ad421a37c7869711a35 %N 3 %0 Journal Article %J Journal of Molecular Neuroscience %D 2004 %T Familial amyloidotic polyneuropathy: Protein aggregation in the peripheral nervous system %A Saraiva, M.J. %A Sousa, M.M. %A Cardoso, I. %A Fernandes, R. %B Journal of Molecular Neuroscience %V 23 %P 35 - 40 %8 2004/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-4344714361&partnerID=40&md5=152a756a10973eda3ac48698f109d97e %N 1-2 %0 Journal Article %J European Journal of Human Genetics %D 2004 %T Haplotypes and DNA sequence variation within and surrounding the transthyretin gene: Genotype-phenotype correlations in familial amyloid polyneuropathy (V30M) in Portugal and Sweden %A Soares, M.L. %A Coelho, T. %A Sousa, A. %A Holmgren, G. %A Saraiva, M.J. %A Kastner, D.L. %A Buxbaum, J.N. %B European Journal of Human Genetics %V 12 %P 225 - 237 %8 2004/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-14044249894&partnerID=40&md5=94a6faea11a6ff3a4fb2858157c278f9 %N 3 %0 Journal Article %J Amyloid %D 2004 %T Mutant fibrinogen A-α-chain associated with hereditary renal amyloidosis and peripheral neuropathy %A De Carvalho, M. %A Linke, R.P. %A Domingos, F. %A Evangelista, T. %A Ducla-Soares, J.L. %A Nathrath, W.B.J. %A Azevedo-Coutinho, C. %A Lima, R. %A Saraiva, M.J. %B Amyloid %V 11 %P 200 - 207 %8 2004/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-4744342551&partnerID=40&md5=cbdf25390f4229553eb4e01ce35d1b8f %N 3 %0 Journal Article %J Biochemical Journal %D 2004 %T Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative %A Almeida, M.R. %A Macedo, B. %A Cardoso, I. %A Alves, I. %A Valencia, G. %A Arsequell, G. %A Planas, A. %A Saraiva, M.J. %B Biochemical Journal %V 381 %P 351 - 356 %8 2004/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-3242807241&partnerID=40&md5=747dfb0a22bc2fdaf7dab5fea48b8f21 %N 2 %0 Journal Article %J Journal of Biological Chemistry %D 2004 %T Transthyretin, a new cryptic protease %A Liz, M.A. %A Faro, C.J. %A Saraiva, M.J. %A Sousa, M.M. %B Journal of Biological Chemistry %V 279 %P 21431 - 21438 %8 2004/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-2442635419&partnerID=40&md5=45c725a0c00b20f0a6ecbf9032fc2cc8 %N 20