%0 Journal Article %J Scientific Reports %D 2017 %T Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation %A Sant'Anna, R. %A Almeida, M.R. %A Varejao, N. %A Gallego, P. %A Esperante, S. %A Ferreira, P. %A Pereira-Henriques, A. %A Palhano, F.L. %A De Carvalho, M. %A Foguel, D. %A Reverter, D. %A Saraiva, M.J. %A Ventura, S. %B Scientific Reports %V 7 %8 2017 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-85016162023&doi=10.1038%2fsrep44709&partnerID=40&md5=6051bd41c380b3c50cbaccf2b26a80af %0 Journal Article %J Scientific Reports %D 2016 %T Curcumin: A multi-Target disease-modifying agent for late-stage transthyretin amyloidosis %A Ferreira, N. %A Gonçalves, N.P. %A Saraiva, M.J. %A Almeida, M.R. %B Scientific Reports %V 6 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84969921377&doi=10.1038%2fsrep26623&partnerID=40&md5=6dba1ba0bad80de99de6426044ae291c %0 Journal Article %J European Journal of Medicinal Chemistry %D 2016 %T A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition %A Simões, C.J.V. %A Almeida, Z.L. %A Costa, D. %A Jesus, C.S.H. %A Cardoso, A.L. %A Almeida, M.R. %A Saraiva, M.J. %A Pinho e Melo, T.M.V.D. %A Brito, R.M.M. %B European Journal of Medicinal Chemistry %V 121 %P 823 - 840 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961839171&doi=10.1016%2fj.ejmech.2016.02.074&partnerID=40&md5=0f10f2da86425912e522ce94860d41a3 %0 Journal Article %J Nature Communications %D 2016 %T Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity %A Sant'Anna, R. %A Gallego, P. %A Robinson, L.Z. %A Pereira-Henriques, A. %A Ferreira, N. %A Pinheiro, F. %A Esperante, S. %A Pallares, I. %A Huertas, O. %A Almeida, M.R. %A Reixach, N. %A Insa, R. %A Velazquez-Campoy, A. %A Reverter, D. %A Reig, N. %A Ventura, S. %B Nature Communications %V 7 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84959087061&doi=10.1038%2fncomms10787&partnerID=40&md5=3e7387be5aa84dc7acb440550ae5e2ec %0 Journal Article %J Biochemistry and Biophysics Reports %D 2015 %T Transthyretin chemical chaperoning by flavonoids: Structure-activity insights towards the design of potent amyloidosis inhibitors %A Ferreira, N. %A Pereira-Henriques, A. %A Almeida, M.R. %B Biochemistry and Biophysics Reports %V 3 %P 123 - 133 %8 2015 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84939508272&partnerID=40&md5=0689f3aa27b7e487c210e2c3353bc19a %0 Journal Article %J Biochimica et Biophysica Acta - Molecular Basis of Disease %D 2013 %T Dietary curcumin counteracts extracellular transthyretin deposition: Insights on the mechanism of amyloid inhibition %A Ferreira, N. %A Santos, S. A. O. %A Domingues, M. R. M. %A Saraiva, M.J. %A Almeida, M.R. %B Biochimica et Biophysica Acta - Molecular Basis of Disease %V 1832 %P 39 - 45 %8 2013/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84868592337&partnerID=40&md5=647a1c6ab2e5ab9f8d22abea13273854 %N 1 %0 Journal Article %J FEBS Letters %D 2012 %T Clearance of extracellular misfolded proteins in systemic amyloidosis: Experience with transthyretin %A Almeida, M.R. %A Saraiva, M.J. %B FEBS Letters %V 586 %P 2891 - 2896 %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84864931018&partnerID=40&md5=7e26ae250f6b885e94435e7a9b447aae %N 18 %0 Journal Article %J PLoS ONE %D 2012 %T Epigallocatechin-3-gallate as a potential therapeutic drug for TTR-related amyloidosis: "In vivo" evidence from FAP mice models %A Ferreira, N. %A Saraiva, M.J. %A Almeida, M.R. %B PLoS ONE %V 7 %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84855650426&partnerID=40&md5=3a4219629a4b3d658732a82d3448a7e4 %N 1 %0 Journal Article %J Amyloid %D 2012 %T Natural polyphenols as modulators of TTR amyloidogenesis: In vitro and in vivo evidences towards therapy %A Ferreira, N. %A Saraiva, M.J. %A Almeida, M.R. %B Amyloid %V 19 %P 39 - 42 %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84861433687&partnerID=40&md5=850a84457e12b3b1a1ebabc339a6f5c8 %N SUPPL. 1 %0 Journal Article %J Current Medicinal Chemistry %D 2012 %T Transthyretin deposition in familial amyloidotic polyneuropathy %A Saraiva, M.J. %A Magalhaes, J. %A Ferreira, N. %A Almeida, M.R. %B Current Medicinal Chemistry %V 19 %P 2304 - 2311 %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84860663436&partnerID=40&md5=962004f2e8e201193cd9a0e0f5657bee %N 15 %0 Journal Article %J FEBS Letters %D 2011 %T Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation %A Ferreira, N. %A Saraiva, M.J. %A Almeida, M.R. %B FEBS Letters %V 585 %P 2424 - 2430 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-79960910835&partnerID=40&md5=280da17ba91b02d23308cfcba9f21a31 %N 15 %0 Journal Article %J BMC Plant Biology %D 2010 %T Functional characterization of Arabidopsis thaliana transthyretin-like protein %A Pessoa, J. %A Sárkány, Z. %A Ferreira-Da-Silva, F. %A Martins, S. %A Almeida, M.R. %A Li, J. %A Damas, A.M. %B BMC Plant Biology %V 10 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-77949472438&partnerID=40&md5=c7268ff6b1d99880ceaf1c6cf6512157 %0 Journal Article %J FEBS Journal %D 2010 %T Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin %A Martinho, A. %A Gonçalves, I. %A Cardoso, I. %A Almeida, M.R. %A Quintela, T. %A Saraiva, M.J. %A Santos, C.R.A. %B FEBS Journal %V 277 %P 3427 - 3436 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-77955239777&partnerID=40&md5=8e3d909df1ca346d05af4045651d0b7d %N 16 %0 Journal Article %J FEBS Letters %D 2009 %T Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity %A Ferreira, N. %A Cardoso, I. %A Domingues, M.R. %A Vitorino, R. %A Bastos, M. %A Bai, G. %A Saraiva, M.J. %A Almeida, M.R. %B FEBS Letters %V 583 %P 3569 - 3576 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-71749085436&partnerID=40&md5=811ef79e7b3739a73a8a833f12c37ec5 %N 22 %0 Journal Article %J PLoS ONE %D 2009 %T Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors. %A Mairal, T. %A Nieto, J. %A Pinto, M. %A Almeida, M.R. %A Gales, L. %A Ballesteros, A. %A Barluenga, J. %A Pérez, J.J. %A Vázquez, J.T. %A Centeno, N.B. %A Saraiva, M.J. %A Damas, A.M. %A Planas, A. %A Arsequell, G. %A Valencia, G. %B PLoS ONE %V 4 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-59249100931&partnerID=40&md5=f198d6ea26cef74066becb41f537c7cd %N 1 %0 Journal Article %J PLoS ONE %D 2009 %T Iodine atoms: A new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors %A Mairal, T. %A Nieto, J. %A Pinto, M. %A Almeida, M.R. %A Gales, L. %A Ballesteros, A. %A Barluenga, J. %A Pérez, J.J. %A Vázquez, J.T. %A Centeno, N.B. %A Saraiva, M.J. %A Damas, A.M. %A Planas, A. %A Arsequell, G. %A Valencia, G. %B PLoS ONE %V 4 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-76549107471&partnerID=40&md5=3c50b3f528228e1cdcbdf338d86ca8ca %N 1 %0 Journal Article %J Bioorganic and Medicinal Chemistry Letters %D 2009 %T Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors %A González, A. %A Quirante, J. %A Nieto, J. %A Almeida, M.R. %A Saraiva, M.J. %A Planas, A. %A Arsequell, G. %A Valencia, G. %B Bioorganic and Medicinal Chemistry Letters %V 19 %P 5270 - 5273 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-68549085257&partnerID=40&md5=b4cf7ffd46ddb61e0d802b209c39334d %N 17 %0 Journal Article %J Biochemical Journal %D 2009 %T Substrate specificity of transthyretin: Identification of natural substrates in the nervous system %A Liz, M.A. %A Fleming, C.E. %A Nunes, A.F. %A Almeida, M.R. %A Mar, F.M. %A Choe, Y. %A Craik, C.S. %A Powers, J.C. %A Bogyo, M. %A Sousa, M.M. %B Biochemical Journal %V 419 %P 467 - 474 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-64249132020&partnerID=40&md5=1051f7c3a610d20ad4abb5e20dbd9dc3 %N 2 %0 Journal Article %J Biochimica et Biophysica Acta - Molecular Basis of Disease %D 2008 %T Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy %A Macedo, B. %A Batista, A.R. %A Ferreira, N. %A Almeida, M.R. %A Saraiva, M.J. %B Biochimica et Biophysica Acta - Molecular Basis of Disease %V 1782 %P 517 - 522 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-49349097870&partnerID=40&md5=0504bdb8449a5ce447da5feb06674ee6 %N 9 %0 Journal Article %J Biochimica et Biophysica Acta - Proteins and Proteomics %D 2008 %T Iodination of salicylic acid improves its binding to transthyretin %A Gales, L. %A Almeida, M.R. %A Arsequell, G. %A Valencia, G. %A Saraiva, M.J. %A Damas, A.M. %B Biochimica et Biophysica Acta - Proteins and Proteomics %V 1784 %P 512 - 517 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-43049162388&partnerID=40&md5=ef1bf96239ccea9c357c15a1c430e7d9 %N 3 %0 Journal Article %J Biochemical Journal %D 2007 %T Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: Relevance in drug design %A Cardoso, I. %A Almeida, M.R. %A Ferreira, N. %A Arsequell, G. %A Valencia, G. %A Saraiva, M.J. %B Biochemical Journal %V 408 %P 131 - 138 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-36348960658&partnerID=40&md5=a11be6d9183785b213d1ee7ad796276b %N 1 %0 Journal Article %J Microbes and Infection %D 2007 %T Interaction with human plasminogen system turns on proteolytic activity in Streptococcus agalactiae and enhances its virulence in a mouse model %A Magalhães, V. %A Veiga-Malta, I. %A Almeida, M.R. %A Baptista, M. %A Ribeiro, A. %A Trieu-Cuot, P. %A Ferreira, P. %B Microbes and Infection %V 9 %P 1276 - 1284 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-35148826082&partnerID=40&md5=837fad04bb1154c2afcf7ec011494e55 %N 11 %0 Journal Article %J Current Drug Targets: CNS and Neurological Disorders %D 2005 %T Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses %A Almeida, M.R. %A Gales, L. %A Damas, A.M. %A Cardoso, I. %A Saraiva, M.J. %B Current Drug Targets: CNS and Neurological Disorders %V 4 %P 587 - 596 %8 2005/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-26844484754&partnerID=40&md5=af4ca78d8342a69428684780d78b9e87 %N 5 %0 Journal Article %J Biochemical Journal %D 2004 %T Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative %A Almeida, M.R. %A Macedo, B. %A Cardoso, I. %A Alves, I. %A Valencia, G. %A Arsequell, G. %A Planas, A. %A Saraiva, M.J. %B Biochemical Journal %V 381 %P 351 - 356 %8 2004/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-3242807241&partnerID=40&md5=747dfb0a22bc2fdaf7dab5fea48b8f21 %N 2