%0 Journal Article %J Journal of Biological Chemistry %D 2017 %T Calcium and magnesium ions modulate the oligomeric state and function of mitochondrial 2-Cys peroxiredoxins in Leishmania parasites %A Morais, M.A.B. %A Giuseppe, P.O. %A Souza, T.A.C.B. %A Castro, H. %A Honorato, R.V. %A Oliveira, P.S.L. %A Netto, L.E.S. %A Tomás, A.M. %A Murakami, M.T. %B Journal of Biological Chemistry %V 292 %P 7023 - 7039 %8 2017 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018327120&doi=10.1074%2fjbc.M116.762039&partnerID=40&md5=5c37d5af11d1e0c95c90b5db0bc55c81 %N 17 %0 Journal Article %J Immunobiology %D 2017 %T Leishmania infantum antigens modulate memory cell subsets of liver resident T lymphocyte %A Rodrigues, A. %A Claro, M. %A Alexandre-Pires, G. %A Santos-Mateus, D. %A Martins, C. %A Valério-Bolas, A. %A Rafael-Fernandes, M. %A Pereira, M.A. %A Pereira da Fonseca, I. %A Tomás, A.M. %A Santos-Gomes, G. %B Immunobiology %V 222 %P 409 - 422 %8 2017 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84995474939&doi=10.1016%2fj.imbio.2016.08.009&partnerID=40&md5=b9a52254b89ea8238d8654427467f999 %N 2 %0 Journal Article %J Comparative Immunology, Microbiology and Infectious Diseases %D 2017 %T Leishmania infantum exerts immunomodulation in canine Kupffer cells reverted by meglumine antimoniate %A Rodrigues, A. %A Santos-Mateus, D. %A Alexandre-Pires, G. %A Valério-Bolas, A. %A Rafael-Fernandes, M. %A Pereira, M.A. %A Ligeiro, D. %A de Jesus, J. %A Alves-Azevedo, R. %A Lopes-Ventura, S. %A Santos, M. %A Tomás, A.M. %A Pereira da Fonseca, I. %A Santos-Gomes, G. %B Comparative Immunology, Microbiology and Infectious Diseases %V 55 %P 42 - 52 %8 2017 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031108841&doi=10.1016%2fj.cimid.2017.09.004&partnerID=40&md5=bf7c1289e03ad324e1091d90b44a9280 %0 Journal Article %J Gene %D 2017 %T Thaulin-1: The first antimicrobial peptide isolated from the skin of a Patagonian frog Pleurodema thaul (Anura: Leptodactylidae: Leiuperinae) with activity against Escherichia coli %A Marani, M.M. %A Perez, L.O. %A de Araujo, A.R. %A Plácido, A. %A Sousa, C.F. %A Quelemes, P.V. %A Oliveira, M. %A Gomes-Alves, A.G. %A Pueta, M. %A Gameiro, P. %A Tomás, A.M. %A Delerue-Matos, C. %A Eaton, P. %A Camperi, S.A. %A Basso, N.G. %A de Souza de Almeida Leite, J.R. %B Gene %V 605 %P 70 - 80 %8 2017 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009376393&doi=10.1016%2fj.gene.2016.12.020&partnerID=40&md5=1235d5db58331193567b9b6db2aaa24a %0 Journal Article %J International Journal for Parasitology: Drugs and Drug Resistance %D 2016 %T Decreased antimony uptake and overexpression of genes of thiol metabolism are associated with drug resistance in a canine isolate of Leishmania infantum %A Gómez Pérez, V. %A García-Hernandez, R. %A Corpas-López, V. %A Tomás, A.M. %A Martín-Sanchez, J. %A Castanys, S. %A Gamarro, F. %B International Journal for Parasitology: Drugs and Drug Resistance %V 6 %P 133 - 139 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84974604096&doi=10.1016%2fj.ijpddr.2016.04.003&partnerID=40&md5=f6041602b4b2e8877608d3b1f5123ca5 %N 2 %0 Journal Article %J Biopolymers %D 2016 %T Ocellatin-PT antimicrobial peptides: High-resolution microscopy studies in antileishmania models and interactions with mimetic membrane systems %A Oliveira, M. %A Gomes-Alves, A.G. %A Sousa, C. %A Mirta Marani, M. %A Pl�cido, A. %A Vale, N. %A Delerue-Matos, C. %A Gameiro, P. %A K�ckelhaus, S.A.S. %A Tomás, A.M. %A S. A. Leite, J.R. %A Eaton, P. %B Biopolymers %P 873 - 886 %8 2016 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988353434&doi=10.1002%2fbip.22925&partnerID=40&md5=bcb19c0a2451ebb4f96282050c0e65c3 %0 Journal Article %J Molecular Microbiology %D 2015 %T LiZIP3 is a cellular zinc transporter that mediates the tightly regulated import of zinc in Leishmania infantum parasites %A Carvalho, S. %A Barreira da Silva, R. %A Shawki, A. %A Castro, H. %A Lamy, M. %A Eide, D. %A Costa, V. %A Mackenzie, B. %A Tomás, A.M. %B Molecular Microbiology %V 96 %P 581 - 595 %8 2015 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84928391014&partnerID=40&md5=911a63ea26163d8928a5159d61ab7052 %N 3 %0 Journal Article %J Proceedings of the National Academy of Sciences of the United States of America %D 2015 %T Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum %A Teixeira, F. %A Castro, H. %A Cruz, T. %A Tse, E. %A Koldewey, P. %A Southworth, D.R. %A Tomás, A.M. %A Jakob, U. %A Craig, E.A. %B Proceedings of the National Academy of Sciences of the United States of America %V 112 %P E616 - E624 %8 2015 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84923301607&partnerID=40&md5=8996b698fbf9422b32fc4a367c775350 %N 7 %0 Journal Article %J Comparative Immunology, Microbiology and Infectious Diseases %D 2015 %T New insights into neutrophil and Leishmania infantum in vitro immune interactions %A Marques, C.S. %A Passero, L.F.D. %A Vale-Gato, I. %A Rodrigues, A. %A Rodrigues, O.R. %A Martins, C. %A Correia, I. %A Tomás, A.M. %A Alexandre-Pires, G. %A Ferronha, M.H. %A Santos-Gomes, G.M. %B Comparative Immunology, Microbiology and Infectious Diseases %V 40 %P 19 - 29 %8 2015 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84929712437&partnerID=40&md5=b7ab10ad727ad3c96fb87095539d1aa8 %0 Book %B Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) %D 2013 %T Automatic spectral unmixing of Leishmania infection macrophage cell cultures image %A Ferro, L. %A Marques, M. %A Leal, P. %A Romão, S. %A Cruz, T. %A Tomás, A.M. %A Castro, H. %A Quelhas, P. %B Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) %V 7950 LNCS %P 621 - 629 %8 2013 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84884486489&partnerID=40&md5=7337706ba8b1e06b68d54fde944f112d %0 Book Section %B Trypanosomatid Diseases: Molecular Routes to Drug Discovery %D 2013 %T Glyoxalase Enzymes in Trypanosomatids %A Silva, M.S. %A Ferreira, A.E.N. %A Gomes, R. %A Tomás, A.M. %A Freire, A.P. %A Cordeiro, C. %B Trypanosomatid Diseases: Molecular Routes to Drug Discovery %P 153 - 166 %8 2013 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84879020447&partnerID=40&md5=b1c335324720e501e3c22255aaaffd43 %0 Journal Article %J Antioxidants and Redox Signaling %D 2013 %T Redox metabolism in mitochondria of trypanosomatids %A Tomás, A.M. %A Castro, H. %B Antioxidants and Redox Signaling %V 19 %P 696 - 707 %8 2013 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84875699740&partnerID=40&md5=34256e52b0a0b5c20c5a76ed69fece99 %N 7 %0 Book Section %B Trypanosomatid Diseases: Molecular Routes to Drug Discovery %D 2013 %T Thiol Peroxidases of Trypanosomatids %A Castro, H. %A Tomás, A.M. %B Trypanosomatid Diseases: Molecular Routes to Drug Discovery %P 201 - 213 %8 2013 %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84886470740&partnerID=40&md5=3bf3d8ad9c51050ea19e83c1dc17532f %0 Journal Article %J International Journal of Medical Microbiology %D 2012 %T The glyoxalase pathway in protozoan parasites %A Sousa Silva, M. %A Ferreira, A.E.N. %A Gomes, R. %A Tomás, A.M. %A Ponces Freire, A. %A Cordeiro, C. %B International Journal of Medical Microbiology %V 302 %P 225 - 229 %8 2012/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-84866632897&partnerID=40&md5=a1fd1e207c4a31e4b494c93d614f3bc7 %N 4-5 %0 Journal Article %J Experimental Parasitology %D 2011 %T Enlightening the molecular basis of trypanothione specificity in trypanosomatids: Mutagenesis of Leishmania infantum glyoxalase II %A Barata, L. %A Sousa Silva, M. %A Schuldt, L. %A Ferreira, A.E.N. %A Gomes, R.A. %A Tomás, A.M. %A Weiss, M.S. %A Ponces Freire, A. %A Cordeiro, C. %B Experimental Parasitology %V 129 %P 402 - 408 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-80455122647&partnerID=40&md5=3821769e665ac666ae26a10c16012a67 %N 4 %0 Journal Article %J PLoS Pathogens %D 2011 %T Leishmania mitochondrial peroxiredoxin plays a crucial peroxidase-unrelated role during infection: Insight into its novel chaperone activity %A Castro, H. %A Teixeira, F. %A Romao, S. %A Santos, M. %A Cruz, T. %A Flórido, M. %A Appelberg, R. %A Oliveira, P. %A Ferreira-Da-Silva, F. %A Tomás, A.M. %B PLoS Pathogens %V 7 %8 2011/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-80055096383&partnerID=40&md5=8bd03c5f9e7d3f02f8423e638a72ed65 %N 10 %0 Journal Article %J Acta Crystallographica Section F: Structural Biology and Crystallization Communications %D 2010 %T Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of glyoxalase i from Leishmania infantum %A Barata, L. %A Sousa Silva, M. %A Schuldt, L. %A Da Costa, G. %A Tomás, A.M. %A Ferreira, A.E.N. %A Weiss, M.S. %A Ponces Freire, A. %A Cordeiro, C. %B Acta Crystallographica Section F: Structural Biology and Crystallization Communications %V 66 %P 571 - 574 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-77951993959&partnerID=40&md5=33f9c58588590dbe65dd6a1da2dc2032 %N 5 %0 Journal Article %J PLoS ONE %D 2010 %T Mitochondrial redox metabolism in trypanosomatids is independent of tryparedoxin activity %A Castro, H. %A Romao, S. %A Carvalho, S. %A Teixeira, F. %A Sousa, C. %A Tomás, A.M. %B PLoS ONE %V 5 %P 1 - 12 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-77958569303&partnerID=40&md5=50742e34f8b472955518907eb41e466e %N 9 %0 Journal Article %J In Vivo %D 2010 %T A possible key molecule for the invasion of the Plasmodium berghei ookinetes into the midgut epithelium of anopheles gambiae mosquitoes %A Toubarro, D.N. %A Ralha, D. %A Carvalho, S. %A Tomás, A.M. %A Almeida, P.G. %B In Vivo %V 24 %P 271 - 280 %8 2010/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-77954091598&partnerID=40&md5=20c94fa65a927f330330cc6e88bfbc74 %N 3 %0 Journal Article %J International Journal for Parasitology %D 2009 %T The cytosolic tryparedoxin of Leishmania infantum is essential for parasite survival %A Romao, S. %A Castro, H. %A Sousa, C. %A Carvalho, S. %A Tomás, A.M. %B International Journal for Parasitology %V 39 %P 703 - 711 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-61349124238&partnerID=40&md5=fdd298c1de935eeeae20e403cbdf92f3 %N 6 %0 Journal Article %J Acta Tropica %D 2009 %T Heme as a source of iron to Leishmania infantum amastigotes %A Carvalho, S. %A Cruz, T. %A Santarém, N. %A Castro, H. %A Costa, V. %A Tomás, A.M. %B Acta Tropica %V 109 %P 131 - 135 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-57849159746&partnerID=40&md5=65b19f8c82455e781c2e01499a47d46b %N 2 %0 Journal Article %J Human Immunology %D 2009 %T Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis %A Fialho, R.N. %A Martins, L. %A Pinheiro, J.P. %A Bettencourt, B.F. %A Couto, A.R. %A Santos, M.R. %A Peixoto, M.J. %A Garrett, F. %A Leal, J. %A Tomás, A.M. %A Bruges-Armas, J. %B Human Immunology %V 70 %P 915 - 920 %8 2009/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-70350026682&partnerID=40&md5=d40023e7f492399eba384539303fce10 %N 11 %0 Journal Article %J Biochemistry %D 2008 %T Catalysis and structural properties of Leishmania infantum glyoxalase II: Trypanothione specificity and phylogeny %A Silva, M.S. %A Barata, L. %A Ferreira, A.E.N. %A Romão, S. %A Tomás, A.M. %A Freire, A.P. %A Cordeiro, C. %B Biochemistry %V 47 %P 195 - 204 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-37849007277&partnerID=40&md5=4fe0ce6aef6282e845478c17ec426e06 %N 1 %0 Journal Article %J Experimental Parasitology %D 2008 %T Leishmania infantum: Provision of reducing equivalents to the mitochondrial tryparedoxin/tryparedoxin peroxidase system %A Castro, H. %A Romao, S. %A Gadelha, F.R. %A Tomás, A.M. %B Experimental Parasitology %V 120 %P 421 - 423 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-55049141724&partnerID=40&md5=436c28ad5570f9cfe402295b56947956 %N 4 %0 Journal Article %J Antioxidants and Redox Signaling %D 2008 %T Peroxidases of trypanosomatids %A Castro, H. %A Tomás, A.M. %B Antioxidants and Redox Signaling %V 10 %P 1593 - 1606 %8 2008/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-46449133760&partnerID=40&md5=e2e09a842e734cd8b3392f35172e17a6 %N 9 %0 Journal Article %J Molecular Immunology %D 2007 %T Cloning, promoter analysis and expression in response to bacterial exposure of sea bass (Dicentrarchus labrax L.) interleukin-12 p40 and p35 subunits %A Nascimento, D.S. %A Vale, A.D. %A Tomás, A.M. %A Zou, J. %A Secombes, C.J. %A dos Santos, N.M.S. %B Molecular Immunology %V 44 %P 2277 - 2291 %8 2007/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33846202982&partnerID=40&md5=1bd3087fffac376cd3598434dc08b7a5 %N 9 %0 Journal Article %J Acta Crystallographica Section F: Structural Biology and Crystallization Communications %D 2006 %T Purification, crystallization and preliminary X-ray diffraction analysis of the glyoxalase II from Leishmania infantum %A Barata, L. %A Sousa Silva, M. %A Trincão, J. %A Carvalho, S. %A Ferreira, A.E.N. %A Bonifácio, C. %A Cordeiro, C. %A Tomás, A.M. %A Ponces Freire, A. %A Romão, M.J. %B Acta Crystallographica Section F: Structural Biology and Crystallization Communications %V 62 %P 805 - 807 %8 2006/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-33747177058&partnerID=40&md5=43ed860cd2bf952404894b74c7d498f1 %N 8 %0 Journal Article %J FEBS Journal %D 2005 %T Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation %A Silva, M.S. %A Ferreira, A.E.N. %A Tomás, A.M. %A Cordeiro, C. %A Freire, A.P. %B FEBS Journal %V 272 %P 2388 - 2398 %8 2005/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-18944383472&partnerID=40&md5=a363ea797ed2bc7459ba9a920c4b97b1 %N 10 %0 Journal Article %J Molecular and Biochemical Parasitology %D 2004 %T Two linked genes of Leishmania infantum encode tryparedoxins localised to cytosol and mitochondrion %A Castro, H. %A Sousa, C. %A Novais, M. %A Santos, M. %A Budde, H. %A Cordeiro-da-Silva, A. %A Flohé, L. %A Tomás, A.M. %B Molecular and Biochemical Parasitology %V 136 %P 137 - 147 %8 2004/// %G eng %U http://www.scopus.com/inward/record.url?eid=2-s2.0-2942562566&partnerID=40&md5=f618cf7f24c87fdb935009018efd9e8b %N 2