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Journal Article
Saraiva, M. J., Magalhaes, J., Ferreira, N., & Almeida, M. R. (2012). Transthyretin deposition in familial amyloidotic polyneuropathy. Current Medicinal Chemistry, 19(15), 2304 - 2311.
Ferreira, N., Pereira-Henriques, A., & Almeida, M. R. (2015). Transthyretin chemical chaperoning by flavonoids: Structure-activity insights towards the design of potent amyloidosis inhibitors. Biochemistry and Biophysics Reports, 3, 123 - 133.
Liz, M. A., Fleming, C. E., Nunes, A. F., Almeida, M. R., et al. (2009). Substrate specificity of transthyretin: Identification of natural substrates in the nervous system. Biochemical Journal, 419(2), 467 - 474.
Almeida, M. R., Gales, L., Damas, A. M., Cardoso, I., & Saraiva, M. J. (2005). Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses. Current Drug Targets: CNS and Neurological Disorders, 4(5), 587 - 596.
Almeida, M. R., Macedo, B., Cardoso, I., Alves, I., et al. (2004). Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative. Biochemical Journal, 381(2), 351 - 356.
Sant'Anna, R., Gallego, P., Robinson, L. Z., Pereira-Henriques, A., et al. (2016). Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity. Nature Communications, 7.
Simões, C. J. V., Almeida, Z. L., Costa, D., Jesus, C. S. H., et al. (2016). A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition. European Journal of Medicinal Chemistry, 121, 823 - 840.
Ferreira, N., Saraiva, M. J., & Almeida, M. R. (2011). Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation. FEBS Letters, 585(15), 2424 - 2430.
Ferreira, N., Saraiva, M. J., & Almeida, M. R. (2012). Natural polyphenols as modulators of TTR amyloidogenesis: In vitro and in vivo evidences towards therapy. Amyloid, 19(SUPPL. 1), 39 - 42.
González, A., Quirante, J., Nieto, J., Almeida, M. R., et al. (2009). Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors. Bioorganic and Medicinal Chemistry Letters, 19(17), 5270 - 5273.
Mairal, T., Nieto, J., Pinto, M., Almeida, M. R., et al. (2009). Iodine atoms: A new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors. PLoS ONE, 4(1).
Mairal, T., Nieto, J., Pinto, M., Almeida, M. R., et al. (2009). Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors. PLoS ONE, 4(1).
Gales, L., Almeida, M. R., Arsequell, G., Valencia, G., et al. (2008). Iodination of salicylic acid improves its binding to transthyretin. Biochimica et Biophysica Acta - Proteins and Proteomics, 1784(3), 512 - 517.
Magalhães, V., Veiga-Malta, I., Almeida, M. R., Baptista, M., et al. (2007). Interaction with human plasminogen system turns on proteolytic activity in Streptococcus agalactiae and enhances its virulence in a mouse model. Microbes and Infection, 9(11), 1276 - 1284.
Martinho, A., Gonçalves, I., Cardoso, I., Almeida, M. R., et al. (2010). Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin. FEBS Journal, 277(16), 3427 - 3436.
Pessoa, J., Sárkány, Z., Ferreira-Da-Silva, F., Martins, S., et al. (2010). Functional characterization of Arabidopsis thaliana transthyretin-like protein. BMC Plant Biology, 10.
Ferreira, N., Saraiva, M. J., & Almeida, M. R. (2012). Epigallocatechin-3-gallate as a potential therapeutic drug for TTR-related amyloidosis: "In vivo" evidence from FAP mice models. PLoS ONE, 7(1).
Ferreira, N., Santos, S. A. O., Domingues, M. R. M., Saraiva, M. J., & Almeida, M. R. (2013). Dietary curcumin counteracts extracellular transthyretin deposition: Insights on the mechanism of amyloid inhibition. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1832(1), 39 - 45.
Ferreira, N., Gonçalves, N. P., Saraiva, M. J., & Almeida, M. R. (2016). Curcumin: A multi-Target disease-modifying agent for late-stage transthyretin amyloidosis. Scientific Reports, 6.
Cardoso, I., Almeida, M. R., Ferreira, N., Arsequell, G., et al. (2007). Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: Relevance in drug design. Biochemical Journal, 408(1), 131 - 138.
Almeida, M. R., & Saraiva, M. J. (2012). Clearance of extracellular misfolded proteins in systemic amyloidosis: Experience with transthyretin. FEBS Letters, 586(18), 2891 - 2896.
Sant'Anna, R., Almeida, M. R., Varejao, N., Gallego, P., et al. (2017). Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation. Scientific Reports, 7.
Ferreira, N., Cardoso, I., Domingues, M. R., Vitorino, R., et al. (2009). Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity. FEBS Letters, 583(22), 3569 - 3576.
Macedo, B., Batista, A. R., Ferreira, N., Almeida, M. R., & Saraiva, M. J. (2008). Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1782(9), 517 - 522.

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