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Author Title [ Type(Desc)] Year
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Journal Article
Batista, A. R., Sena-Esteves, M., & Saraiva, M. J. (2013). Hepatic production of transthyretin L12P leads to intracellular lysosomal aggregates in a new somatic transgenic mouse model. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1832(8), 1183 - 1193.
Petrakis, I., Mavroeidi, V., Stylianou, K., Andronikidi, E., et al. (2013). Hsf-1 affects podocyte markers NPHS1, NPHS2 and WT1 in a transgenic mouse model of TTRVal30Met-related amyloidosis. Amyloid, 20(3), 164 - 172.
Martinho, A., Gonçalves, I., Cardoso, I., Almeida, M. R., et al. (2010). Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin. FEBS Journal, 277(16), 3427 - 3436.
Gales, L., Macedo-Ribeiro, S., Arsequell, G., Valencia, G., et al. (2005). Human transthyretin in complex with iododiflunisal: Structural features associated with a potent amyloid inhibitor. Biochemical Journal, 388(2), 615 - 621.
Petrakis, I., Mavroeidi, V., Stylianou, K., Efthymiou, G., et al. (2013). Human TTRV30M localization within podocytes in a transgenic mouse model of transthyretin related amyloidosis: Does the environment play a role?. Transgenic Research, 22(1), 101 - 116.
Terazaki, H., Ando, Y., Fernandes, R., Yamamura, K. - I., et al. (2006). Immunization in familial amyloidotic polyneuropathy: Counteracting deposition by immunization with a Y78F TTR mutant. Laboratory Investigation, 86(1), 23 - 31.
Teixeira, C. A., Almeida, M. D. R., & Saraiva, M. J. (2016). Impairment of autophagy by TTR V30M aggregates: In vivo reversal by TUDCA and curcumin. Clinical Science, 130(18), 1665 - 1675.
Santos, S. D., Cardoso, I., Magalhães, J., & Saraiva, M. J. (2007). Impairment of the ubiquitin-proteasome system associated with extracellular transthyretin aggregates in familial amyloidotic polyneuropathy. Journal of Pathology, 213(2), 200 - 209.
Gonçalves, N. P., Martins, D., & Saraiva, M. J. (2017). The importance of pre-clinical studies in animal models of TTR amyloidosis for the discovery of novel patient disease biomarkers. Amyloid, 24, 83 - 84.
Monteiro, F. A., Cardoso, I., Sousa, M. M., & Saraiva, M. J. (2006). In vitro inhibition of transthyretin aggregate-induced cytotoxicity by full and peptide derived forms of the soluble receptor for advanced glycation end products (RAGE). FEBS Letters, 580(14), 3451 - 3456.
Gonçalves, N. P., Teixeira-Coelho, M., & Saraiva, M. J. (2014). The inflammatory response to sciatic nerve injury in a familial amyloidotic polyneuropathy mouse model. Experimental Neurology, 257, 76 - 87.
Gales, L., Almeida, M. R., Arsequell, G., Valencia, G., et al. (2008). Iodination of salicylic acid improves its binding to transthyretin. Biochimica et Biophysica Acta - Proteins and Proteomics, 1784(3), 512 - 517.
Mairal, T., Nieto, J., Pinto, M., Almeida, M. R., et al. (2009). Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors. PLoS ONE, 4(1).
Mairal, T., Nieto, J., Pinto, M., Almeida, M. R., et al. (2009). Iodine atoms: A new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors. PLoS ONE, 4(1).
González, A., Quirante, J., Nieto, J., Almeida, M. R., et al. (2009). Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors. Bioorganic and Medicinal Chemistry Letters, 19(17), 5270 - 5273.
Martins, D., Moreira, J., Gonçalves, N. P., & Saraiva, M. J. (2017). MMP-14 overexpression correlates with the neurodegenerative process in familial amyloidotic polyneuropathy. DMM Disease Models and Mechanisms, 10(10), 1253 - 1260.
Pansieri, J., Plissonneau, M., Stransky-Heilkron, N., Dumoulin, M., et al. (2017). Multimodal imaging Gd-nanoparticles functionalized with Pittsburgh compound B or a nanobody for amyloid plaques targeting. Nanomedicine, 12(14), 1675 - 1687.
De Carvalho, M., Linke, R. P., Domingos, F., Evangelista, T., et al. (2004). Mutant fibrinogen A-α-chain associated with hereditary renal amyloidosis and peripheral neuropathy. Amyloid, 11(3), 200 - 207.
Ferreira, N., Saraiva, M. J., & Almeida, M. R. (2012). Natural polyphenols as modulators of TTR amyloidogenesis: In vitro and in vivo evidences towards therapy. Amyloid, 19(SUPPL. 1), 39 - 42.
Ferreira, N., Saraiva, M. J., & Almeida, M. R. (2011). Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation. FEBS Letters, 585(15), 2424 - 2430.
Simões, C. J. V., Almeida, Z. L., Costa, D., Jesus, C. S. H., et al. (2016). A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition. European Journal of Medicinal Chemistry, 121, 823 - 840.
Gonçalves, N. P., Oliveira, H., Pêgo, A. P., & Saraiva, M. J. (2012). A novel nanoparticle delivery system for in vivo targeting of the sciatic nerve: Impact on regeneration. Nanomedicine, 7(8), 1167 - 1180.
Gonçalves, N. P., Martins, D., & Saraiva, M. J. (2016). Overexpression of Protocadherin-10 in Transthyretin-Related Familial Amyloidotic Polyneuropathy. American Journal of Pathology, 186(7), 1913 - 1924.
Conejos-Sánchez, I., Cardoso, I., Oteo-Vives, M., Romero-Sanz, E., et al. (2015). Polymer-doxycycline conjugates as fibril disrupters: An approach towards the treatment of a rare amyloidotic disease. Journal of Controlled Release, 198, 80 - 90.
Butler, J. S., Chan, A., Costelha, S., Fishman, S., et al. (2016). Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis. Amyloid, 23(2), 109 - 118.

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