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Journal Article
Ribeiro, C. A., Oliveira, S. M., Guido, L. F., Magalhães, A., et al. (2014). Transthyretin stabilization by iododiflunisal promotes amyloid-β peptide clearance, decreases its deposition, and ameliorates cognitive deficits in an Alzheimer's disease mouse model. Journal of Alzheimer's Disease, 39(2), 357 - 370.
Alemi, M., Silva, S. C., Santana, I., & Cardoso, I. (2017). Transthyretin stability is critical in assisting beta amyloid clearance– Relevance of transthyretin stabilization in Alzheimer's disease. CNS Neuroscience and Therapeutics, 23(7), 605 - 619.
Costa, R., Ferreira-Da-Silva, F., Saraiva, M. J., & Cardoso, I. (2008). Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: A mechanism sensitive to the kunitz protease inhibitor. PLoS ONE, 3(8).
Alemi, M., Gaiteiro, C., Ribeiro, C. A., Santos, L. M., et al. (2016). Transthyretin participates in beta-amyloid transport from the brain to the liver- involvement of the low-density lipoprotein receptor-related protein 1?. Scientific Reports, 6.
Silva, C. S., Eira, J., Ribeiro, C. A., Oliveira, Â., et al. (2017). Transthyretin neuroprotection in Alzheimer's disease is dependent on proteolysis. Neurobiology of Aging, 59, 10 - 14.
Ribeiro, C. A., Santana, I., Oliveira, C., Baldeiras, I., et al. (2012). Transthyretin decrease in plasma of MCI and AD patients: Investigation of mechanisms for disease modulation. Current Alzheimer Research, 9(8), 881 - 889.
Costa, R., Gonçalves, A., Saraiva, M. J., & Cardoso, I. (2008). Transthyretin binding to A-Beta peptide - Impact on A-Beta fibrillogenesis and toxicity. FEBS Letters, 582(6), 936 - 942.
Sousa, J. C., Cardoso, I., Marques, F., Saraiva, M. J., & Palha, J. A. (2007). Transthyretin and Alzheimer's disease: Where in the brain?. Neurobiology of Aging, 28(5), 713 - 718.
Costa, R., Speretta, E., Crowther, D. C., & Cardoso, I. (2011). Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease. Journal of Biological Chemistry, 286(48), 41647 - 41655.
Conejos-Sánchez, I., Cardoso, I., Saraiva, M. J., & Vicent, M. J. (2014). Targeting a rare amyloidotic disease through rationally designed polymer conjugates. Journal of Controlled Release, 178(1), 95 - 100.
Cardoso, I., Martins, D., Ribeiro, T., Merlini, G., & Saraiva, M. J. (2010). Synergy of combined Doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: Studies in FAP mouse models. Journal of Translational Medicine, 8.
Ribeiro, C. A., Saraiva, M. J., & Cardoso, I. (2012). Stability of the Transthyretin Molecule as a Key Factor in the Interaction with A-Beta Peptide - Relevance in Alzheimer's Disease. PLoS ONE, 7(9).
Almeida, M. R., Gales, L., Damas, A. M., Cardoso, I., & Saraiva, M. J. (2005). Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses. Current Drug Targets: CNS and Neurological Disorders, 4(5), 587 - 596.
Cristóvão, J. S., Leal, S. S., Cardoso, I., & Gomes, C. M. (2013). Small molecules present in the cerebrospinal fluid metabolome influence superoxide dismutase 1 aggregation. International Journal of Molecular Sciences, 14(9), 19128 - 19145.
Almeida, M. R., Macedo, B., Cardoso, I., Alves, I., et al. (2004). Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative. Biochemical Journal, 381(2), 351 - 356.
Santos, L. M., Rodrigues, D., Alemi, M., Silva, S. C., et al. (2016). Resveratrol administration increases transthyretin protein levels, ameliorating AD features: The importance of transthyretin tetrameric stability. Molecular Medicine, 22, 597 - 607.
Saraiva, A. M., Cardoso, I., Saraiva, M. J., Tauer, K., et al. (2010). Randomization of Amyloid-β-Peptide(1-42) Conformation by Sulfonated and Sulfated Nanoparticles Reduces Aggregation and Cytotoxicity. Macromolecular Bioscience, 10(10), 1152 - 1163.
Conejos-Sánchez, I., Cardoso, I., Oteo-Vives, M., Romero-Sanz, E., et al. (2015). Polymer-doxycycline conjugates as fibril disrupters: An approach towards the treatment of a rare amyloidotic disease. Journal of Controlled Release, 198, 80 - 90.
Carvalho, S. B., Botelho, H. M., Leal, S. S., Cardoso, I., et al. (2013). Intrinsically Disordered and Aggregation Prone Regions Underlie β-Aggregation in S100 Proteins. PLoS ONE, 8(10).
Gimeno, A., Santos, L. M., Alemi, M., Rivas, J., et al. (2017). Insights on the Interaction between Transthyretin and Aβ in Solution. A Saturation Transfer Difference (STD) NMR Analysis of the Role of Iododiflunisal. Journal of Medicinal Chemistry, 60(13), 5749 - 5758.
Monteiro, F. A., Cardoso, I., Sousa, M. M., & Saraiva, M. J. (2006). In vitro inhibition of transthyretin aggregate-induced cytotoxicity by full and peptide derived forms of the soluble receptor for advanced glycation end products (RAGE). FEBS Letters, 580(14), 3451 - 3456.
Santos, S. D., Cardoso, I., Magalhães, J., & Saraiva, M. J. (2007). Impairment of the ubiquitin-proteasome system associated with extracellular transthyretin aggregates in familial amyloidotic polyneuropathy. Journal of Pathology, 213(2), 200 - 209.
Martinho, A., Gonçalves, I., Cardoso, I., Almeida, M. R., et al. (2010). Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin. FEBS Journal, 277(16), 3427 - 3436.
Oliveira, S. M., Ribeiro, C. A., Cardoso, I., & Saraiva, M. J. (2011). Gender-dependent transthyretin modulation of brain amyloid-β Levels: Evidence from a mouse model of alzheimer's disease. Journal of Alzheimer's Disease, 27(2), 429 - 439.
Saraiva, M. J., Sousa, M. M., Cardoso, I., & Fernandes, R. (2004). Familial amyloidotic polyneuropathy: Protein aggregation in the peripheral nervous system. Journal of Molecular Neuroscience, 23(1-2), 35 - 40.


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