Anti-parasitic drug discovery: from in vitro screening to animal validation
15 SEPTEMBER 2014 | IBMC - Porto – Portugal

The possibility to perform live imaging, from cells to animals, has greatly contributed to the advance of several fields of research including drug-discovery. Understanding how high- throughput high-content screening microscopes and small animal live imaging can be used to discover and validate new anti-parasitic drugs is the goal of this workshop.

The High-Throughput High-Content screening microscope allows analysis of multiplexed quantitative data based on automated cell imaging. Whole animal live imaging systems to detect fluorescence or bioluminescence can be used to evaluate and monitor drugs efficiency and kinetics.

This workshop provides an opened half day with specialized people. Limited places are available for a half day laboratory training on throughput high content screening and whole animal live imaging.

PROGRAMME

08.30 – 09.00  Welcome Participants

09.00 – 09.20  Opening Talk

09.20 – 10.10 Sarman Singh, New Delhi, India
Overview of current affairs in terms of clinical leishmaniasis and medical aspects as well as drug treatments, drug resistance in the field.

10.10 – 11.00  James McKerrow, UCSF
Drug discovery: High-throughput screening.

11.00 – 11.30 Coffee-Break

11.30 – 12.30  Rogerio Amino, Institut Pasteur, Paris
In vivo imaging to discover new anti-parasitic approaches.

12.30 – 14.00 Lunch

PARALLEL PRACTICAL SESSIONS

14.00 – 15.45 

SESSION A: Joana Tavares, IBMC and Jair Neto, UCSF
Evaluating anti-parasitic drugs efficiency using bioluminescent whole animal imaging system.

SESSION B: Andre Maia, IBMC
High-throughput drug screening using the IN Cell Analyzer (GE Healthcare)

16.15 – 18.00   REPETITION OF BOTH SESSIONS

The event is free but the registration is mandatory:
http://www.ibmc.up.pt/eventos/registrationnew.php?eid=49
Practical sessions registration deadline: 27^th August
Practical sessions will be available for a limited number of participants. The participants selected to the practical sessions will be contacted by e-mail on 3^rd September.

Scientific  and Organizing Committees:
Anabela Cordeiro, FFUP and IBMC, Portugal
Joana Tavares, IBMC, Portugal
André Maia, IBMC, Portugal