Cytoskeletal mechanisms of axonal growth and regeneration

Friday, October 26, 2012
Frank Bradke
Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE), Germany



FRIDAY NOON SEMINARS | OCT 26 | 12H00 | MAIN AUDITORIUM

Frank Bradke is a Group Leader at the German Center for Neurodegenerative Diseases (DZNE) in Bonn where the major goal of his lab is to understand how axonal growth is regulated. Frank has several seminal contributions in the field of axonal growth and regeneration, including the development of new tools for in vivo imaging.

For more info: http://www.dzne.de/en/centers/bonn-cologne-juelich/research-groups/bradke.html

 

Selected publications (Frank Bradke, 2010-2012):

- Bradke F, Fawcett JW, Spira ME. Assembly of a new growth cone after axotomy: the precursor to axon regeneration. Nat Rev Neurosci. 2012 Feb 15;13(3):183-93.

- Ertürk A, Mauch CP, Hellal F, Förstner F, Keck T, Becker K, Jährling N, Steffens H, Richter M, Hübener M, Kramer E, Kirchhoff F, Dodt HU, Bradke F. Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury. Nat Med. 2011 Dec 25;18(1):166-71.

- Hellal F, Hurtado A, Ruschel J, Flynn KC, Laskowski CJ, Umlauf M, Kapitein LC, Strikis D, Lemmon V, Bixby J, Hoogenraad CC, Bradke F. Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. Science. 2011 Feb 18;331(6019):928-31.

- Stiess M, Bradke F. Controlled demolition: Smurf1 regulates neuronal polarity by substrate switching. Neuron. 2011 Jan 27;69(2):183-5.

- Stiess M, Bradke F. Neuronal transport: myosins pull the ER. Nat Cell Biol. 2011 Jan;13(1):10-1.

- Enes J, Langwieser N, Ruschel J, Carballosa-Gonzalez MM, Klug A, Traut MH, Ylera B, Tahirovic S, Hofmann F, Stein V, Moosmang S, Hentall ID, Bradke F. Electrical activity suppresses axon growth through Ca(v)1.2 channels in adult primary sensory neurons. Curr Biol. 2010 Jul 13;20(13):1154-64.

- Stiess M, Maghelli N, Kapitein LC, Gomis-Rüth S, Wilsch-Bräuninger M, Hoogenraad CC, Tolić-Nørrelykke IM, Bradke F. Axon extension occurs independently of centrosomal microtubule nucleation. Science. 2010 Feb 5;327(5966):704-7.
 

POSTER DOWNLOAD

 

 

 



Home | Site Map | Contacts | Credits | Privacy & Cookies | WHISTLEBLOWER CHANNEL | Intranet | Social Networks |


rua alfredo allen, 208, 4200-135 porto - portugal | tel +351 226 074 900 | email: info@i3s.up.pt | © copyright 2010 ibmc