Funding

 

Designação do projeto: Structured Program on Bioengineered Therapies for Infectious Diseases and Tissue Regeneration

Código do projeto: NORTE-01-0145-FEDER-000012
Objetivo principal: Reforçar a investigação, o desenvolvimento tecnológico e a inovação
Região de intervenção: Norte
Entidade beneficiária: IBMC – Instituto Biologia Molecular e Celular
Data de aprovação: 08-04-2016
Data de início: 01-05-2016
Data de conclusão: 30-04-2019
Custo total elegível: 2,295,000 EUR
Apoio financeiro da União Europeia: 1,950,750 EUR
Apoio financeiro público nacional/regional: 344,250 EUR

Objetivos, atividades e resultados esperados/atingidos:
The current Program aims to understand and decipher the complex crosstalk that takes place between the host immune system and foreign entities, namely pathogens and bioengineered materials, with the final goal of proposing new combinatorial therapeutic strategies to fight disease and improve patients quality of life. By combining knowledge and expertise in different fields and encompassing research in several related and complementary areas, it represents a unique opportunity to tackle complex problems on infection, immunity and tissue repair.

 

 

Designação do projeto: “Porto Neurosciences and Neurologic Disease Research Initiative at i3S”- Iniciativa em Neurociências e Doenças Neurológicas do Porto no i3S

Código do projeto: NORTE-01-0145-FEDER-000008
Objetivo principal: Reforçar a investigação, o desenvolvimento tecnológico e a inovação
Região de intervenção: Norte
Entidade beneficiária: IBMC – Instituto Biologia Molecular e Celular
Data de aprovação: 23-03-2016
Data de início: 01-05-2016
Data de conclusão: 30-04-2019
Custo total elegível: 4.724.658,30 EUR
Apoio financeiro da União Europeia: 4.015.959,56 EUR
Apoio financeiro público nacional/regional: 708.698,75 EUR

Objetivos, atividades e resultados esperados/atingidos:
A iniciativa em Pesquisa em Neurociências e Doenças Neurológicas do Porto no i3S (PortoNeuroDRIve@i3S) proposta pelo IBMC em co-promoção com o INEB e o IPATIMUP, tem como principal objectivo a realização e promoção de pesquisa fundamental, aplicada e clínica na área das Neurociências no i3S. Esta iniciativa envolve 22 grupos de pesquisa divididos por 4 linhas de pesquisa com objectivos científicos independentes mas complementares, e que em conjunto formam um programa interdisciplinar, coerente e em sintonia com o nosso objectivo de contribuir para dotar o i3S com massa crítica, conhecimento avançado, tecnologia sofisticada e notoriedade internacional para a produção de ciência e inovação de grande nível, particularmente na área das Neurociências. O PortoNeuroDRIve@i3S tem também como objectivos treinar, recrutar e manter neurocientistas de grande talento e motivação; de consolidar ou estabelecer novas parcerias com empresas, institutos de investigação, universidades e entidades públicas.

 

 

Designação do projeto: ADVANCING CANCER RESEARCH: FROM BASIC KNOWLEDGE TO APPLICATION

Código do projeto: NORTE-01-0145-FEDER-000029
Objetivo principal: Reforçar a investigação, o desenvolvimento tecnológico e a inovação
Região de intervenção: Norte
Entidade beneficiária: IBMC – Instituto Biologia Molecular e Celular
Data de aprovação: 13-04-2016
Data de início: 01-05-2016
Data de conclusão: 30-04-2019
Custo total elegível: 1.274.498 EUR
Apoio financeiro da União Europeia: 1.083.323,30 EUR
Apoio financeiro público nacional/regional: 191.174,70 EUR

Objetivos, atividades e resultados esperados/atingidos:
This Structured R&D&I project integrates five Research lines (RL) on human cancer addressing different aspects of tumor development and different types of tumors. The ultimate purpose of the project is the prevention, early diagonis, surveillance and contribution for public management of cancer. Thus, it is fully framed in the societal challenge " Health, Demographic Change and Wellbeing", established by the European Union for the "Horizon 2020 - Framework Programme for research and Innovation". The objectives are common to the five RL's: Finding new methods and/or new biomarkers for improving the diagnosis, the prognosis and/or the targeted treatment of patients with cancerous lesions.

 

 

Projeto NGS - Sequenciação de Nova Geração em Neurogenética:

Start date: January 2011. Duration 55 months

The project NGS - Sequenciação de Nova Geração em Neurogenética, reference NORTE-07-0162-FEDER-000135, was funded by Programa Operacional Regional do Norte (ON.2—O Novo Norte), under the Quadro de Referência Estratégico Nacional (QREN), through the Fundo Europeu de Desenvolvimento Regional (FEDER).
The main general objectives of this research project are to consolidate the knowledge and expertise in Center for predictive and preventive genetic, and keep up technological developments in the DNA sequencing, the next generation sequencing (NGS), through the development and validation of gene panels for genetic characterization of patients with different neurological diseases.
The project allows also the enhanced of the human capital expertise in the CGPP, as well as the development of the site www.testegenetico.com.

 

Projeto Neurogenerative Disorders:

Start date: January 2013. Duration 30 months

The project Neurogenerative Disorders, reference NORTE-07-0124-FEDER-000001, was funded by Programa Operacional Regional do Norte (ON.2—O Novo Norte), under the Quadro de  ReferênciaEstratégico Nacional (QREN), through the Fundo Europeu de Desenvolvimento Regional (FEDER) and by FCT (Fundação para a Ciência e Tecnologia).

The main general objectives of this research project are to consolidate ongoing studies at IBMC in the area of Neurodegenerative Diseases and to develop new interface areas that interlink researchers within this field.

This interdisciplinary proposal takes advantage of the knowledge and expertise of different research groups at IBMC developing different lines of research involving genetic and epigenetic studies, structural and cell biology, development of animal models, translational research and clinical studies.

 

Projeto Host-Pathogen Interactions:

Start date: December 2013. Duration 19 months

The project Host-Pathogen Interactions, reference NORTE-07-0124-FEDER-000002, was funded by Programa Operacional Regional do Norte (ON.2—O Novo Norte), under the Quadro de  Referência Estratégico Nacional (QREN), through the Fundo Europeu de Desenvolvimento Regional (FEDER) and by FCT (Fundação para a Ciência e Tecnologia).

 

The interaction between pathogens and their hosts is a complex and dynamic event, with each player having to recognize, respond and adapt to the other. Pathogens have evolved strategies to manipulate and evade host defenses to optimize their survival and/or transmission. Meanwhile, the host defense system must balance the requirement to control the pathogen with the potential for damaging its own tissues. An infection is thus accompanied by responses from both the pathogen and the host and it is the balance between these responses that defines the infection outcome.

The project aims at identifying and studying the molecules and pathways that play critical roles during the interaction of pathogens with their hosts. We examine host-pathogen interactions from both angles: the virulence mechanisms employed by pathogens to infect, colonize and persist in their hosts, and the mechanisms engaged by the host to resist infection at the cellular and organism levels. In addition, we analyze the mechanisms of pathology induction and investigate potential therapeutic and preventive strategies. The research uses in vivo and in vitro experimental models of host-pathogen interactions: from bacteria and fungi to parasites, from extracellular to obligate intracellular pathogens, and from cultured human cells to mouse and fish animal models.

 

Projeto Cell Homeostasis Tissue Organization and Organism Biology:

Start date: January 2013. Duration 30 months

The project Cell Homeostasis Tissue Organization and Organism Biology (reference: NORTE-07-0124-FEDER-000003) was funded by Programa Operacional Regional do Norte (ON.2—O Novo Norte), under the Quadro de Referência Estratégico Nacional (QREN), Fundo Europeu de Desenvolvimento Regional (FEDER) and by FCT (Fundação para a Ciência e Tecnologia).

This research project aims to study some of the basic mechanisms underlying biological organization, including  cellular homeostasis, tissue growth and organization, and evolution. To gain insight into these different levels of organization it is critical to develop new and more comprehensive unifying models of how complex biological systems work. Ultimately this understanding can be used to design better therapeutic strategies to fight a wide range of diseases.



Projeto Beyond TT:

Start date: December 2013. Duration 19 months

The project Beyond TT (reference: NORTE-07-0124-FEDER-000004) was funded by Programa Operacional Regional do Norte (ON.2—O Novo Norte), under the Quadro de  Referência Estratégico Nacional (QREN), through the Fundo Europeu de Desenvolvimento Regional (FEDER) and by FCT (Fundação para a Ciência e Tecnologia).

IBMC understands that translation of research results into innovation and value for society is a central task of a research institution. Beyond TT is a translational project that updates the procedures applied by the IBMC for technology transfer.

 

 

Projeto MICROXXI:
The project MICROXXI - Atualização das infraestruturas científicas de microscopia do IBMC, reference NORTE-07-0162-FEDER-000033, was funded by ON2 for capacity building, enabling the core facilities: Advance Light Microscopy (ALM), Histology and Electron Microscopy Service (HEMS) and Advanced Flow Cytometry Unit (AFCU) to provide new services.

 

Projeto IET:

The IBMC applied to the ON2 program the project IET - Reforço de competências tecnológicas, reference NORTE-01-0162-FEDER-000029 with three main lines, to achieve efficiencies in its technological competence Center for predictive and preventive genetic.
It was possible, cumulatively, to better integrate this center in this Institute and link it with other core facilities of IBMC, including the Animal Facility, and CCGen and to increase the services available to comunity.

 


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