SEMINAR | 6 MAY 2015 | 14:00 | IBMC AUDITORIUM B
Size matters: mechanisms controlling flagellum length in trypanosomes
Philippe Bastin, Trypanosome Cell Biology Unit, Pasteur Institute, Paris

Trypanosomes are flagellated parasites responsible for sleeping sickness in central Africa. They are transmitted by the bite of the tsetse fly where they develop first in the midgut, then transit to the proventriculus to ultimately reach the salivary gland where fresh infective parasites are produced. During this complex life cycle, the length of their flagellum varies between 3 and 30 µm. Here, we have investigated the mechanisms that could control flagellum length using a combination of reverse genetics and live cell imaging.
Bastin is the head of Trypanosome Cell Biology Unit of Pasteur Institute in Paris since 2010. The Unit is also affiliated to the Department of Parasites and Insect Vectors and the Department of Cell Biology and Infection. The Unit also belongs to a larger CNRS unit (URA2581, headed by Artur Scherf) that involves three other teams working on Plasmodium and on Leishmania. The lab is also a member of the LabEx IBEID coordinated by Pascale Cossart and Philippe Sansonetti.

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