CID - Chromosome Instability & Dynamics Lab |
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Welcome to the Maiato lab

The gift of the great microscopist is the ability to think with the eyes
and see with the brain.

Daniel Mazia


The cell is always speaking
- the secret is to learn its language.

Andrew S. Bajer

Chromosome Instability & Dynamics Lab


Mitosis is the process by which the nuclear material is divided and transmitted to the next generation of cells in eukaryotic organisms. It is not only an essential process for life, but mitotic abnormalities have also been related with aneuploidy and chromosomal instability observed in many human cancers. Aneuploidy is also the basis of many birth defects and the main cause of spontaneous abortions in humans. Clearly, elucidating the molecular mechanisms behind chromosome segregation fidelity will have broad biological significance, while contributing to unveil the routes of aneuploidy and their implications to human health/disease. The major goal of our laboratory is to understand how chromosome segregation is regulated in time and space and how mitotic failure may lead to aneuploidy, contributing to a better understanding of how cancer arises and how it could be treated.

In the lab

Current members of the lab & alumni
Learn about our current projects
The facilities and tools that make our work possible
Protocols – some of our optimized recipes


  • Prometaphase
  • Chromosomal instability: Stretching the role of checkpoint silencing
  • SOGA1 and SOGA2/MTCL1 are CLASP-interacting proteins required for faithful chromosome segregation in human cells