Funding

Projeto IET:

The IBMC applied to the ON2 program the project IET - Reforço de competências tecnológicas, reference NORTE-01-0162-FEDER-000029 with three main lines, to achieve efficiencies in its technological competence Center for predictive and preventive genetic.
It was possible, cumulatively, to better integrate this center in this Institute and link it with other core facilities of IBMC, including the Animal Facility, and CCGen and to increase the services available to comunity.

 

Projeto MICROXXI:
The project MICROXXI - Atualização das infraestruturas científicas de microscopia do IBMC, reference NORTE-07-0162-FEDER-000033, was funded by ON2 for capacity building, enabling the core facilities: Advance Light Microscopy (ALM), Histology and Electron Microscopy Service (HEMS) and Advanced Flow Cytometry Unit (AFCU) to provide new services.

Projeto Neurogenerative Disorders:

Start date: January 2013. Duration 30 months

The project Neurogenerative Disorders, reference NORTE-07-0124-FEDER-000001, was funded by Programa Operacional Regional do Norte (ON.2—O Novo Norte), under the Quadro de  ReferênciaEstratégico Nacional (QREN), through the Fundo Europeu de Desenvolvimento Regional (FEDER) and by FCT (Fundação para a Ciência e Tecnologia).

The main general objectives of this research project are to consolidate ongoing studies at IBMC in the area of Neurodegenerative Diseases and to develop new interface areas that interlink researchers within this field.

This interdisciplinary proposal takes advantage of the knowledge and expertise of different research groups at IBMC developing different lines of research involving genetic and epigenetic studies, structural and cell biology, development of animal models, translational research and clinical studies.

Projeto Host-Pathogen Interactions:

Start date: December 2013. Duration 19 months

The project Host-Pathogen Interactions, reference NORTE-07-0124-FEDER-000002, was funded by Programa Operacional Regional do Norte (ON.2—O Novo Norte), under the Quadro de  Referência Estratégico Nacional (QREN), through the Fundo Europeu de Desenvolvimento Regional (FEDER) and by FCT (Fundação para a Ciência e Tecnologia).

 

The interaction between pathogens and their hosts is a complex and dynamic event, with each player having to recognize, respond and adapt to the other. Pathogens have evolved strategies to manipulate and evade host defenses to optimize their survival and/or transmission. Meanwhile, the host defense system must balance the requirement to control the pathogen with the potential for damaging its own tissues. An infection is thus accompanied by responses from both the pathogen and the host and it is the balance between these responses that defines the infection outcome.

The project aims at identifying and studying the molecules and pathways that play critical roles during the interaction of pathogens with their hosts. We examine host-pathogen interactions from both angles: the virulence mechanisms employed by pathogens to infect, colonize and persist in their hosts, and the mechanisms engaged by the host to resist infection at the cellular and organism levels. In addition, we analyze the mechanisms of pathology induction and investigate potential therapeutic and preventive strategies. The research uses in vivo and in vitro experimental models of host-pathogen interactions: from bacteria and fungi to parasites, from extracellular to obligate intracellular pathogens, and from cultured human cells to mouse and fish animal models.

Projeto Cell Homeostasis Tissue Organization and Organism Biology:

Start date: January 2013. Duration 30 months

The project Cell Homeostasis Tissue Organization and Organism Biology (reference: NORTE-07-0124-FEDER-000003) was funded by Programa Operacional Regional do Norte (ON.2—O Novo Norte), under the Quadro de Referência Estratégico Nacional (QREN), Fundo Europeu de Desenvolvimento Regional (FEDER) and by FCT (Fundação para a Ciência e Tecnologia).

This research project aims to study some of the basic mechanisms underlying biological organization, including  cellular homeostasis, tissue growth and organization, and evolution. To gain insight into these different levels of organization it is critical to develop new and more comprehensive unifying models of how complex biological systems work. Ultimately this understanding can be used to design better therapeutic strategies to fight a wide range of diseases.



Projeto Beyond TT:

Start date: December 2013. Duration 19 months

The project Beyond TT (reference: NORTE-07-0124-FEDER-000004) was funded by Programa Operacional Regional do Norte (ON.2—O Novo Norte), under the Quadro de  Referência Estratégico Nacional (QREN), through the Fundo Europeu de Desenvolvimento Regional (FEDER) and by FCT (Fundação para a Ciência e Tecnologia).

IBMC understands that translation of research results into innovation and value for society is a central task of a research institution. Beyond TT is a translational project that updates the procedures applied by the IBMC for technology transfer.

 


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